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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626933/
This article will focus on nanosized crystals in medical application. In drug delivery and clinical applications the technology to nanonize (ie, to reduce in size to below 1000 nm) is one of the key factors for modern drug therapy, now and in the years to come. Over the last ten years, the number of poorly soluble drugs has steadily increased.Author: Jens-Uwe A H Junghanns, Rainer H Müller
https://www.researchgate.net/publication/23458143_Nanocrystal_technology_drug_delivery_and_clinical_applications
Introduction Nanocrystals constitutes of 100% drug and considered as a “new drug” by Food and Drug Administration. It is proven to be an effective alternative for topical delivery of drug with ...
https://pdfs.semanticscholar.org/e8c8/f9a0026f7e43106069b70d227383f48c284a.pdf
application. In drug delivery and clinical applications the technology to nanonize (ie, to reduce in size to below 1000 nm) is one of the key factors for modern drug therapy, now and in the years to come. Over the last ten years, the number of poorly soluble drugs has steadily increased.
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.4375
BibTeX @MISC{Junghanns_reviewnanocrystal, author = {Jens-uwe A H Junghanns and Rainer H Müller}, title = {REVIEW Nanocrystal technology, drug delivery and clinical applications}, year = {}}
https://link.springer.com/article/10.1007/s11095-012-0889-z
Oct 17, 2012 · The limited solubility and dissolution rate exhibited by poorly soluble drugs is major challenges in the pharmaceutical process. Following oral administration, the poorly soluble drugs generally show a low and erratic bioavailability which may lead to therapeutic failure. Pure drug nanocrystals, generated by “bottom up” or “top down” technologies, facilitate a significant improvement ...Author: Lei Gao, Guiyang Liu, Jianli Ma, Xiaoqing Wang, Liang Zhou, Xiang Li, Fang Wang
https://www.sciencedirect.com/science/article/pii/S2211383515300319
Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., …Author: Yi Lu, Ye Li, Wei Wu
https://www.dovepress.com/article_metric.php?article_id=2427
Dove Press is a member of the Open Access Initiative, specializing in peer reviewed Medical Journals. View articlesor submit your research for publishingAuthor: Jens-Uwe A H Junghanns, Rainer H Müller
https://www.semanticscholar.org/paper/Nanocrystal-technology%2C-drug-delivery-and-clinical-Junghanns-Mueller/24738d381a6b26807756021f0f1788e927074343
Nanocrystal technology, drug delivery and clinical applications @article{Junghanns2008NanocrystalTD, title={Nanocrystal technology, drug delivery and clinical applications}, author={Jens-Uwe A. H. Junghanns and Rainer Helmut Mueller}, journal={International Journal of Nanomedicine}, year={2008}, volume={3}, pages={295 - 310} } ...
https://pdfs.semanticscholar.org/b2a2/2c584acb2c980b608d2d415a50f285481b26.pdf
characteristics of drug nanocrystals, and to develop feasible nanocrystal applications for ocular and oral drug delivery purposes. Hence, develop-ability issues from the analytical difficulties of the drug dissolution behavior to the scale-ability of the nanocrystals were covered. A …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336669/
Dec 24, 2018 · 3.4. Challenges and criteria in the clinical development of nanocrystal‐drug products. The past two decades witnessed major strides being made in the development of nanocrystal drug technology. A majority of the active pharmaceutical ingredient (API) …Author: Maria Jarvis, Vinu Krishnan, Samir Mitragotri
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