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https://www.pnas.org/content/109/36/14604
Sep 04, 2012 · Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine. Here we show that nonviral delivery of a 9-kb self-amplifying RNA encapsulated within an LNP substantially increased immunogenicity compared with delivery of unformulated RNA.Author: Andrew J. Geall, Ayush Verma, Gillis R. Otten, Christine A. Shaw, Armin Hekele, Kaustuv Banerjee, Ye...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437863/
Sep 04, 2012 · Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine.Author: Andrew J. Geall, Ayush Verma, Gillis R. Otten, Christine A. Shaw, Armin Hekele, Kaustuv Banerjee, Ye...
https://www.pnas.org/content/pnas/109/36/14604.full.pdf
delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine. Here we show that nonviral delivery of a 9-kb self-amplifying RNA encap-sulated within an LNP substantially increased immunogenicity compared with …Author: Andrew J. Geall, Ayush Verma, Gillis R. Otten, Christine A. Shaw, Armin Hekele, Kaustuv Banerjee, Ye...
https://www.researchgate.net/publication/230712385_Nonviral_delivery_of_self-amplifying_RNA_vaccines
Nonviral delivery of self-amplifying RNA vaccines Article (PDF Available) in Proceedings of the National Academy of Sciences 109(36):14604-9 · August 2012 with 422 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pubmed/22908294
Sep 04, 2012 · Here we show that nonviral delivery of a 9-kb self-amplifying RNA encapsulated within an LNP substantially increased immunogenicity compared with delivery of unformulated RNA. This unique vaccine technology was found to elicit broad, potent, and protective immune responses, that were comparable to a viral delivery technology, but without the ...Author: Andrew J. Geall, Ayush Verma, Gillis R. Otten, Christine A. Shaw, Armin Hekele, Kaustuv Banerjee, Ye...
https://www.sciencedirect.com/science/article/pii/S0065266014000066
5. Delivery of Self-Amplifying mRNA Vaccines. A key challenge in realizing the full potential of self-amplifying mRNA vaccines is the efficient nonviral delivery of the nucleic acid to the cell cytoplasm, where it can amplify and express the encoded vaccine antigen.Author: Brito La, Kommareddy S, Maione D, Uematsu Y, Giovani C, Berlanda Scorza F, Otten Gr, Yu D, Mandl Cw,...
https://www.sciencedirect.com/science/article/abs/pii/S0065266014000066
This chapter highlights the rapid progress made in using nonviral delivery systems for RNA-based vaccines. Initial preclinical testing of self-amplifying mRNA vaccines has shown nonviral delivery to be capable of producing potent and robust innate and adaptive immune responses in small animals and nonhuman primates.Author: Brito La, Kommareddy S, Maione D, Uematsu Y, Giovani C, Berlanda Scorza F, Otten Gr, Yu D, Mandl Cw,...
https://www.semanticscholar.org/paper/Nonviral-delivery-of-self-amplifying-RNA-vaccines.-Geall-Verma/ce1aad47be27f89a750b090d9ce1c44ea597adcf
@article{Geall2012NonviralDO, title={Nonviral delivery of self-amplifying RNA vaccines.}, author={Andrew J. Geall and Ayush Verma and Gillis R. Otten and Christine A. Shaw and Armin Hekele and Kaustuv Banerjee and Yen Cu and Clayton W. Beard and Luis A. Brito and Thomas Krucker and Derek T O'hagan ...
https://www.nature.com/articles/gt20175
Jan 17, 2017 · Because of its safe and effective protein expression profile, in vitro transcribed messenger RNA (IVT-mRNA) represents a promising candidate in the development of …Author: S Guan, J Rosenecker
https://europepmc.org/articles/PMC3437863
Europe PMC is an archive of life sciences journal literature. Find the latest peer-reviewed research articles and preprints on Coronavirus here.Author: Andrew J. Geall, Ayush Verma, Gillis R. Otten, Christine A. Shaw, Armin Hekele, Kaustuv Banerjee, Ye...
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