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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292496/
Oct 12, 2007 · NONVIRAL VEHICLES FOR NEURONAL NUCLEIC ACID DELIVERY. Realizing the potential of nonviral gene therapy to neurons will require the development of synthetic vectors that are capable of mediating efficient delivery of therapeutic nucleic acids into the targeted cells.Author: Jamie M. Bergen, In Kyu Park, Philip J. Horner, Suzie H. Pun
https://www.researchgate.net/publication/221819119_Nonviral_Approach_for_Targeted_Nucleic_Acid_Delivery
Cationic peptides, lipoplexes, polyplexes and nanoplexes have been used as carriers for delivery of nucleic acids.
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=19&issue=2&spage=197
Despite their relatively lower efficiency, nonviral approaches are emerging as safer alternatives in gene therapy to viral vectors. Delivery of nucleic acids to the target site is an important factor for effective gene expression (plasmid DNA) or knockdown (siRNA) with minimal side effects.Author: M. Jafari, M. Soltani, S. Naahidi, D. N. Karunaratne, P. Chen
https://www.academia.edu/10830448/Nonviral_Approach_for_Targeted_Nucleic_Acid_Delivery
Despite their relatively lower efficiency, nonviral approaches are emerging as safer alternatives in gene therapy to viral vectors. Delivery of nucleic acids to the target site is an important factor for effective gene expression (plasmid DNA) or
https://link.springer.com/10.1007/s11095-007-9439-5
Considering the numerous barriers encountered in applications of neuron-targeted nucleic acid delivery, the design of effective nonviral vehicles will require an integrated approach that accounts for each of the barriers.Author: Jamie M. Bergen, In Kyu Park, Philip J. Horner, Suzie H. Pun
https://www.intechopen.com/online-first/nucleic-acid-based-therapy-development-of-a-nonviral-based-delivery-approach/
Direct injection to the tissue is the simplest approach for the physical delivery of nucleic acid. The first report for delivery to muscle was published in 1990 [25]. Needle injection was expanded to the skin [26], heart muscle [27], liver [28], and tumor [29].Author: Takeshi Yokoo, Kenya Kamimura, Tsutomu Kanefuji, Takeshi Suda, Shuji Terai
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Physical methods of nonviral gene delivery. Physical methods applied for in vitro and in vivo gene delivery are based on making transient penetration in cell membrane by mechanical, electrical, ultrasonic, hydrodynamic, or laser-based energy so that DNA entrance into the targeted cells …
https://www.researchgate.net/publication/309162697_Non-viral_nucleic_acid_delivery_methods
Introduction: Delivery of nucleic acid-based molecules in human cells is a highly studied approach for the treatment of several disorders including monogenic diseases and cancers.
https://onlinelibrary.wiley.com/doi/full/10.1002/wnan.1634
Abstract Despite the large number of drugs available for the treatment of asthma, in 5–10% of the patients this disease is not well controlled. While most treatments palliate symptoms, those suffer...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/nucleic-acid-delivery
Cationic lipids and cationic polymers have been widely studied in the context of nonviral gene delivery systems. The discovery of lipofection [ 8] has prompted the use of cationic lipids for nucleic acid delivery in vitro and in vivo, and they have also been used in clinical trials of human gene therapy.
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