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https://www.nature.com/articles/nmat2784
Jun 20, 2010 · Here we developed an intranasal vaccine-delivery system with a nanometre-sized hydrogel (‘nanogel’) consisting of a cationic type of cholesteryl-group-bearing pullulan (cCHP). A non-toxic subunit fragment of Clostridium botulinum type-A neurotoxin BoHc/A administered...Author: Tomonori Nochi, Tomonori Nochi, Yoshikazu Yuki, Haruko Takahashi, Shin-ichi Sawada, Mio Mejima, Tomo...
https://www.ncbi.nlm.nih.gov/pubmed/20562880
Moreover, intranasally immunized tetanus toxoid with cCHP nanogel induced strong tetanus-toxoid-specific systemic and mucosal immune responses. These results indicate that cCHP nanogel can be used as a universal protein-based antigen-delivery vehicle for adjuvant-free intranasal vaccination.Author: Tomonori Nochi, Tomonori Nochi, Yoshikazu Yuki, Haruko Takahashi, Shin-ichi Sawada, Mio Mejima, Tomo...
https://www.researchgate.net/profile/Hideo_Tsukada/publication/44902577_Nanogel_antigenic_protein-delivery_system_for_adjuvant-free_intranasal_vaccines/links/0c96053aa06e927a30000000/Nanogel-antigenic-protein-delivery-system-for-adjuvant-free-intranasal-vaccines.pdf
no risk of redirecting the vaccine antigen into the CNS when administered intranasally and, therefore, can be used as a safe deliveryvehicleforintranasalvaccines. In essence, the nanogel antigen delivery system now opens up a new avenue for the creation of adjuvant-free intranasal vaccines.
https://ui.adsabs.harvard.edu/abs/2010NatMa...9..572N/abstract
Jul 01, 2010 · These results indicate that cCHP nanogel can be used as a universal protein-based antigen-delivery vehicle for adjuvant-free intranasal vaccination. Nanotechnology is an innovative method of freely controlling nanometre-sized materials.Author: Tomonori Nochi, Tomonori Nochi, Yoshikazu Yuki, Haruko Takahashi, Shin-ichi Sawada, Mio Mejima, Tomo...
https://www.researchgate.net/publication/44902577_Nanogel_antigenic_protein-delivery_system_for_adjuvant-free_intranasal_vaccines
Nanogel antigenic protein-deliv ery system for adjuvant-free intr anasal vaccines T omonori Nochi, Y oshikazu Y uki, Haruko T akahashi, Shin-ichi Sawada, Mio Mejima, T omoko Kohda, Norihiro Harada,
https://ui.adsabs.harvard.edu/abs/2010NatMa...9..685N/abstract
Aug 01, 2010 · Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccinesAuthor: Tomonori Nochi, Tomonori Nochi, Yoshikazu Yuki, Haruko Takahashi, Shin-ichi Sawada, Mio Mejima, Tomo...
http://www.ims.u-tokyo.ac.jp/imsut/en/research/nanogel_antigenic_proteindeliv.php
Moreover, intranasally immunized tetanus toxoid with cCHP nanogel induced strong tetanus-toxoid-specific systemic and mucosal immune responses. These results indicate that cCHP nanogel can be used as a universal protein-based antigen-delivery vehicle for adjuvant-free intranasal vaccination.
https://marbleo126.brownpromo.co/nanogel-antigenic-protein-delivery-system-for-adjuvant-free-intranasal-vaccines.html?i=www&category=vaccrights-10&fid=20
Nanogel Antigenic Protein Delivery System For Adjuvant Free Intranasal Vaccines On Sale . For many who are looking for Nanogel Antigenic Protein Delivery System For Adjuvant Free Intranasal Vaccines review. We've more details about Detail, Specification, Customer …9.7/10(360.3K)
https://www.tandfonline.com/doi/pdf/10.1080/02648725.2013.801226
domain-mediated protein-delivery systems (Watanabe et al., 2011). Furthermore, the anti-apoptotic protein Bcl-xL delivered by cCHP nanogels efficiently blocked apoptosis of these cells, indicating that the artificial chaperone function of nanogels is a useful tool to deliver proteins and maintain their major bioactivities. Mucosal immune system
https://www.sciencedirect.com/science/article/pii/S0161589017305515
Nanogel-based antigen-delivery systems can apply to both infectious and lifestyle-related diseases. Abstract Because the mucosa is the major entry route for most pathogens, the development of mucosal vaccines is a rational approach for protecting against these undesired agents.Author: Tatsuhiko Azegami, Tatsuhiko Azegami, Yoshikazu Yuki, Rika Nakahashi, Hiroshi Itoh, Hiroshi Kiyono
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