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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626933/
For many applications there is the need to combine drug nanocrystals with traditional controlled release technology (eg, coated pellets) to avoid fast dissolution, excessively high plasma peaks and premature t max, and to reach prolonged blood levels. To summarize, the optimal drug nanocrystal size and crystalline/amorphous state will depend on:Author: Jens-Uwe A H Junghanns, Rainer H Müller
https://www.sciencedirect.com/science/article/pii/S0169409X19300699
Nanocrystals as drug delivery system. Nanocrystals are crystalline drug particles with sizes generally smaller than 1 μm [, , , , , ]. In some cases, surfactants and/or polymers are physically adsorbed on the surface of the nanocrystals to reduce particle aggregation. Doxil® may likely be the ...Author: Yi Lu, Yi Lu, Yongjiu Lv, Tonglei Li
https://www.researchgate.net/publication/281548453_A_Review_on_Nanocrystals_Drug_Delivery_System
A Review on Nanocrystals Drug Delivery System. ... Drug nanocrystals consist of the pure poorly water-soluble drug without any matrix material means carrier free drug delivery system. This opinion ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788714/
In this review, preparative methods for nanocrystals will be briefly introduced, followed by a detailed review on the progress of targeted drug delivery by nanocrystals. Polymer encapsulation to increase nanocrystal stability and immobilize ligands on the surface of nanocrystals will also be included.Author: Yi Lu, Ye Li, Wei Wu
https://www.sciencedirect.com/science/article/pii/S2211383515300319
Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., …Author: Yi Lu, Ye Li, Wei Wu
https://www.researchgate.net/publication/272565469_A_REVIEW_ON_SIGNIFICANCE_OF_NANOCRYSTALS_IN_DRUG_DELIVERY
Nanocrystals, a new carrier-free colloidal drug delivery system with a particle size ranging from 100 to 1000nm, is thought as a viable drug delivery strategy to develop the poorly soluble drugs ...
https://pdfs.semanticscholar.org/b2a2/2c584acb2c980b608d2d415a50f285481b26.pdf
characteristics of drug nanocrystals, and to develop feasible nanocrystal applications for ocular and oral drug delivery purposes. Hence, develop-ability issues from the analytical difficulties of the drug dissolution behavior to the scale-ability of the nanocrystals were covered. A …
https://www.slideshare.net/drshereenshehata/nanocrystals
Jan 26, 2017 · Nanocrystals 1. • Nanocrystals are pure solid drug particles with a size in the nanometer range. • Drug nanocrystals have to be distinguished from polymeric nanoparticles, which consist of a polymeric matrix and an incorporated drug but drug nanocrystals do not consist of any matrix material.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
Sep 19, 2018 · The use of ideal nano-drug delivery system is decided primarily based on the biophysical and biochemical properties of the targeted drugs being selected for the treatment . However, problems such as toxicity exhibited by nanoparticles cannot be ignored when considering the use of nanomedicine.Author: Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto, Leonardo Fernandes Fraceto, Estefani...
https://link.springer.com/article/10.1007%2Fs11705-015-1509-3
Jun 20, 2016 · Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer).Author: Tzu-Lan Chang, Honglei Zhan, Danni Liang, Jun F. Liang
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