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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626933/
In drug delivery and clinical applications the technology to nanonize (ie, to reduce in size to below 1000 nm) is one of the key factors for modern drug therapy, now and in the years to come. Over the last ten years, the number of poorly soluble drugs has steadily increased.Author: Jens-Uwe A H Junghanns, Rainer H Müller
https://pdfs.semanticscholar.org/b2a2/2c584acb2c980b608d2d415a50f285481b26.pdf
the drug nanocrystals are paid a lot of attention as a promising approach due to an increasing number of poorly soluble drugs in the drug development process, pharmacoeconomic value, straightforward production and safe composition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788714/
Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs.Author: Yi Lu, Ye Li, Wei Wu
https://www.sciencedirect.com/science/article/pii/S2211383515300319
Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs.Author: Yi Lu, Ye Li, Wei Wu
http://www.americanpharmaceuticalreview.com/Featured-Articles/331624-Drug-Nanocrystal-Technologies-for-Oral-Drug-Delivery/
Dec 01, 2016 · Drug Nanocrystal Technologies for Oral Drug Delivery. The milling of drug substances to reduce particle size is a common process used in the pharmaceutical industry. Reducing particle size helps achieve uniform distribution of the drug when blended with excipients, which is especially important for low dose products (drug content < 5% w/w).
https://www.researchgate.net/publication/279403770_Cellulose_Nanocrystals_for_Drug_Delivery
Nanotechnology-based drug delivery systems can enhance drug permeation through the skin and improve the drug stability.
https://www.sciencedirect.com/science/article/pii/S0169409X19300699
2.1. Nanocrystals as drug delivery system. Nanocrystals are crystalline drug particles with sizes generally smaller than 1 μm [, , , , , ]. In some cases, surfactants and/or polymers are physically adsorbed on the surface of the nanocrystals to reduce particle aggregation.Author: Yi Lu, Yi Lu, Yongjiu Lv, Tonglei Li
https://pubs.acs.org/doi/abs/10.1021/bk-2009-1017.ch004
Dec 20, 2009 · The lack of toxicity and untargeted uptake support the potential of cellulose nanocrystals as carriers in targeted drug delivery applications.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
Sep 19, 2018 · For drug delivery purposes, the most commonly studied nanocarriers are crystal nanoparticles, liposomes, micelles, polymeric nanoparticles, solid lipid nanoparticles, superparamagnetic iron oxide nanoparticles and dendrimers [228,229,230]. All of these nanocarriers are formulated for natural product based drug delivery.Author: Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto, Leonardo Fernandes Fraceto, Estefani...
https://www.researchgate.net/publication/272565469_A_REVIEW_ON_SIGNIFICANCE_OF_NANOCRYSTALS_IN_DRUG_DELIVERY
Nanocrystal is a new carrier free colloidal drug delivery system with particle size ranging from 100-1000 nm, and is considered as a viable drug delivery strategy to develop the poorly soluble drugs.
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