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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626933/
The same is valid for drug nanoparticles. Amorphous drug nanoparticles possess a higher saturation solubility compared to equally sized drug nanocrystals in the crystalline state. Therefore, to reach the highest saturation solubility increase, a combination of nanometer size and amorphous state is ideal.Author: Jens-Uwe A H Junghanns, Rainer H Müller
https://pdfs.semanticscholar.org/b2a2/2c584acb2c980b608d2d415a50f285481b26.pdf
the drug nanocrystals are paid a lot of attention as a promising approach due to an increasing number of poorly soluble drugs in the drug development process, pharmacoeconomic value, straightforward production and safe composition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788714/
Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs.Author: Yi Lu, Ye Li, Wei Wu
https://www.future-science.com/doi/10.4155/tde-2020-0016
Mar 11, 2020 · Nanocrystals are used as a drug-delivery platform for poorly water-soluble drugs and have had commercial success in oral drug delivery. We assert that the future of this technique is with cancer treatment and in the development of parenteral preparations.Author: Zhongjian Chen, Wei Wu, Wei Wu, Yi Lu, Yi Lu
https://www.sciencedirect.com/science/article/pii/S2211383515300319
Targeted delivery by nanocrystals 3.1. In vivo distribution of nanocrystals. Due to being sequestered and transported by MPS cells, i.v. 3.2. Ligand targeted delivery. To facilitate targeting to cancer cells,... 3.3. Stimuli-responsive drug delivery. Generally, stabilizer adsorbed onto the ...Author: Yi Lu, Ye Li, Wei Wu
https://pubs.acs.org/doi/abs/10.1021/bk-2009-1017.ch004
Dec 20, 2009 · For cellular uptake studies, cellulose nanocrystals were labeled with fluorescein-5'-isothiocyanate. The uptake studies showed minimal uptake of untargeted cellulose nanocrystals. The lack of toxicity and untargeted uptake support the potential of cellulose nanocrystals as carriers in targeted drug delivery applications.
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