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https://www.tandfonline.com/doi/abs/10.1517/17425247.2012.690733
Oct 10, 2008 · The natural polymers have represented the potential to deliver drugs topically through the limited precorneal area and release over a prolonged time period. Areas covered: The important points to be considered during the fabrication of ophthalmic formulations for example, properties of drug molecule and polymer which affect the release rate are discussed.Author: Priyanka Pahuja, Sandeep Arora, Pravin Pawar
https://www.researchgate.net/publication/227163082_Ocular_drug_delivery_system_A_reference_to_natural_polymers
Introduction: Ocular drug delivery is a very challenging endeavor due to the unique anatomical and physiological barriers. The low ocular bioavailability (<10%) obtained from conventional formulations has forced the scientists to develop new formulations to deliver drugs to ocular tissues at a controlled rate to reduce frequent instillations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket . Concentration of drug available in the precorneal area acts as a driving force …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781321/
Sep 06, 2019 · 2. Drug Delivery Systems for Ocular Route. Drop instillation performed by a topical path to deliver a given drug into the lower precorneal segment of the eye is a broadly known method to make an administration with the compliance of the patient.Author: Eliana B. Souto, João Dias-Ferreira, Ana López-Machado, Miren Ettcheto, Amanda Cano, Antonio Camins ...
https://www.researchgate.net/publication/324081123_NATURAL_POLYMERS_USED_FOR_IN_SITU_DRUG_DELIVERY_SYSTEM_A_REVIEW
There is a need to expl ore the abundant natu ral resources for ne w natural polymers. In situ gels provide better bioavailability , formulation stability , prolonged releas e.
https://www.researchgate.net/publication/26267040_In_Situ_Gelling_Polymers_in_Ocular_Drug_Delivery_Systems_A_Review
Ocular drug delivery systems based on polymers offer the considerable advantages of improving drug availability and decreasing side effects compared to conventional therapeutic methods.
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
Consequently it is imperative to optimize ophthalmic drug delivery; one of the way to do so is by addition of polymers of various grades, development of in situ gel or colloidal suspension or ...
https://www.sciencedirect.com/science/article/pii/S1359644607004618
In the in vivo study, niosomes, independent of their pH, significantly improved the ocular bioavailability of cyclopentolate, with respect to reference buffer solution, indicating that it can be used as an efficient vehicle for ocular drug delivery . A modified form of niosomes, the discomes, are also used in ophthalmic drug delivery systems.Author: Sanjeeb K. Sahoo, Fahima Dilnawaz, S. Krishnakumar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681499/
Jul 12, 2019 · The drug delivery system made from chitosan and αβ-glycerophosphate exhibited a thermo-responsive property and was used as a drug delivery system for adriamycin and 6-mercaptopurine . The thermo-responsive hydrogel made of pNIPAAm and chitosan was applied on cotton fabric using glutalraldehyde as a cross-linker to impart antibacterial activity to cotton fabric [ 58 ].Author: Sudipta Chatterjee, Patrick Chi-leung Hui
https://www.researchgate.net/publication/269673076_Natural_Polymers_in_Drug_Delivery
Natural Polymers in Drug Delivery. Polymers have been in use for many years with the aim of facilitating the effectiveness and efficiency of drugs and their delivery. Biodegradable polymers are widely being studied as a potential carrier material for site specific drug delivery because of their non-toxic, biocompatible nature.
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