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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket . Concentration of drug available in the precorneal area acts as a …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.allfordrugs.com/ocular-drug-delivery-systems-an-overview/
Ocular iontophoresis offers a drug delivery system that is fast, painless and safe; and in most cases, it results in the delivery of a high concentration of the drug to a specific site. Increased incidence of bacterial keratitis, frequently resulting in corneal scarring, offers a clinical condition that may benefit from drug delivery by iontophoresis.
https://www.ncbi.nlm.nih.gov/pubmed/25590022
Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of conventional topical formulations such as suspensions, emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · MICRONEEDLE-, ULTRASOUND-, AND IONTOPHORESIS-BASED OCULAR DRUG DELIVERY SYSTEMS. All these delivery systems are noninvasive methods designed to deliver drugs to intraocular regions, mainly for the treatment of posterior segment diseases. Researchers have developed drug-coated microneedles with a length of 500 to 750 µm.Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
A successful design of a drug delivery system, therefore, requires an integrated knowledge of the drug molecule and the constraints offered by the ocular route of administration [3]. The various approaches that have been attempted to increase the bioavailability and the duration of the therapeutic action...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Topical instillation of ophthalmic drops is the most common method used to administer pharmaceutical agents for ocular disease; 90% of ophthalmic drug formulations are for topical drop use. Methods of topical drug delivery include eye drops, ointments, suspensions, contact lenses, and some drug delivery devices.Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.slideshare.net/sujitpatel11/ocular-drug-delivery-system
Feb 10, 2013 · Controlled ocular drug delivery systems increase the efficiency of the drug by reducing its wastage and by enhancing absorption by increasing contact time of drug to the absorbing surface. They improve patient compliance by reducing the frequency of dosing. They reduces the dose and thereby reduces the adverse effects of the drug.February 11, 2013 Dept.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781321/
Sep 06, 2019 · The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even more effective outcomes to their pathologies, surpassing the traditionally-used eye drops.Author: Eliana B. Souto, João Dias-Ferreira, Ana López-Machado, Miren Ettcheto, Amanda Cano, Antonio Camins ...
https://www.slideshare.net/sagarsavale1/ocular-drug-delivery-system-odds-62796410
Jun 07, 2016 · “The Novel approach of drug delivery system in which drug can Instilled on the cull de sac cavity of eye is known has Ocular drug delivery system”. cull de sac cavity: the space between eye lids and eye balls. The most commonly employed ophthalmic dosage forms are solutions, suspensions, and ointments.
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
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