Transdermal Delivery Of Insulin Using Microneedles In Vivo

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Transdermal Delivery of Insulin Using Microneedles in Vivo

    http://drugdelivery.chbe.gatech.edu/Papers/2004/Martanto%20Pharm%20Res%202004.pdf
    transdermal insulin delivery and lowering blood glucose levels by as much as 80% in diabetic hairless rats in vivo . KEY WORDS: diabetes; microelectromechanical systems (MEMS);

Transdermal Delivery of Insulin Using Microneedles in Vivo ...

    https://link.springer.com/article/10.1023%2FB%3APHAM.0000029282.44140.2e
    Jun 01, 2004 · Solid metal microneedles are capable of increasing transdermal insulin delivery and lowering blood glucose levels by as much as 80% in diabetic hairless rats in vivo. This is a preview of subscription content, log in to check access.Author: Wijaya Martanto, Shawn P. Davis, Nicholas R. Holiday, Jenny Wang, Harvinder S. Gill, Mark R. Prausni...

Transdermal delivery of insulin using microneedle rollers ...

    https://www.sciencedirect.com/science/article/pii/S0378517310002152
    Jun 15, 2010 · The enhanced transdermal delivery of insulin was also demonstrated in vivo by effective control of blood glucose level. Taken together, our results demonstrate that the 250- and 500-μm microneedle rollers can pierce the skin during manual application and are the most promising tools for in vivo delivery of biologically active proteins such as insulin.Author: Cui-Ping Zhou, Yu-Ling Liu, Hong-Liang Wang, Peng-Xiao Zhang, Jin-Lan Zhang

Dissolving Microneedle Patches for Transdermal Insulin ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164338/
    Sep 05, 2018 · 3.4. In Vivo Study of Transdermal Delivery of FITC-Insulin from MNs. In order to characterize the skin permeation of FITC-insulin from loaded MNs, patches with and without insulin were applied to mice for 10 min before removal. Using the IVIS, images were captured 10 min, 1 h and 3 h after treatment.Author: Chih-Hao Chen, Victor Bong-Hang Shyu, Chien-Tzung Chen

In vivo monitoring of microneedle-based transdermal drug ...

    https://www.worldscientific.com/doi/pdf/10.1142/S1793545818500323
    transdermal drug delivery because of their excellent biocompatibility and rapid dissolution. However, direct monitoring of structural and functional changes of MNs in vivo to estimate the e±ciency of insulin delivery is di±cult.Author: Jiawei Zhao, Yongbo Wu, Junbo Chen, Bangrong Lu, Honglian Xiong, Zhilie Tang, Yanhong Ji

Microneedles for transdermal delivery of insulin

    https://www.researchgate.net/publication/275466516_Microneedles_for_transdermal_delivery_of_insulin
    Microneedles for transdermal delivery of insulin. Insulin medication is currently effective in the treatment of type I diabetes. Due to the poor absorption or enzymatic degradation of insulin in the gastrointestinal tract and liver, the subcutaneous route has been so far the preferred method of insulin administration.

Microneedles for transdermal delivery of insulin ...

    https://www.sciencedirect.com/science/article/pii/S1773224715000714
    Microneedles (MNs) have been widely studied for transdermal delivery of insulin as minimally invasive and painless in human subjects. This review article focuses on recent and emerging progress in MN technologies utilized for the transdermal delivery of insulin.Author: Song Xie, Zijing Li, Zongqin Yu

Implantable powder-carrying microneedles for transdermal ...

    https://www.sciencedirect.com/science/article/pii/S0142961219308518
    Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity. Author links open overlay panel Suyong Kim a Huisuk Yang b Jaehong Eum a Yonghao Ma a Shayan Fakhraei Lahiji a Hyungil Jung a b. Show more. ... In vivo insulin administration.Author: Suyong Kim, Huisuk Yang, Jaehong Eum, Yonghao Ma, Shayan Fakhraei Lahiji, Hyungil Jung

Intradermal Insulin Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455430/
    Initial studies on microneedle devices revealed that the needles can be inserted into the skin in a predictable manner. 29 The first reports of enhanced transdermal delivery of insulin in vivo regarded the use of solid microneedles for increasing insulin delivery and decreasing blood glucose levels. 30 Later, infusion in vivo and into human cadaver skin also showed promising results. 31,32 In all studies, the human subjects describe microneedle …Author: Michael Hultström, Niclas Roxhed, Lina Nordquist

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