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http://drugdelivery.chbe.gatech.edu/Papers/2004/Martanto%20Pharm%20Res%202004.pdf
of solid microneedles and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to lower blood glucose level. Methods. Arrays containing 105 microneedles were laser-cut from stainless steel metal sheets and inserted into the skin of anesthetized hairless rats with streptozotocin-induced diabetes. During and after
https://www.sciencedirect.com/science/article/pii/S1773224715000714
Microneedles (MNs) have been widely studied for transdermal delivery of insulin as minimally invasive and painless in human subjects. This review article focuses on recent and emerging progress in MN technologies utilized for the transdermal delivery of insulin.Author: Song Xie, Zijing Li, Zongqin Yu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Transdermal delivery of insulin is attractive as a noninvasive method that offers the convenience of a transdermal patch (4). However, the skin’s barrier properties prevent absorption of useful amounts of insulin.Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://link.springer.com/article/10.1023%2FB%3APHAM.0000029282.44140.2e
Jun 01, 2004 · Conclusions. Solid metal microneedles are capable of increasing transdermal insulin delivery and lowering blood glucose levels by as much as 80% in diabetic hairless rats in vivo.Author: Wijaya Martanto, Shawn P. Davis, Nicholas R. Holiday, Jenny Wang, Harvinder S. Gill, Mark R. Prausni...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · This is especially useful for the delivery of high molecular weight compounds such as proteins, oligonucleotides and vaccines. Transdermal delivery of insulin continues to represent a significant scientific challenge. Cheung et al. used 1100 and 1400 µm long stainless steel microneedles to deliver insulin across porcine skin . Two commercial ...Author: Kevin B. Ita
https://www.researchgate.net/publication/275466516_Microneedles_for_transdermal_delivery_of_insulin
Microneedles for transdermal delivery of insulin. Insulin medication is currently effective in the treatment of type I diabetes. Due to the poor absorption or enzymatic degradation of insulin in the gastrointestinal tract and liver, the subcutaneous route has been so far the preferred method of insulin …
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