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https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/transdermal-insulin-delivery/
Passive delivery usually occurs with a patch, cream, or spray. Passive Transdermal delivery only works with small molecule drugs, such as nicotine and aspirin. Insulin is far too large to get through the skin passively. Active transdermal delivery, on the other hand, involves a …
https://www.sciencedirect.com/science/article/pii/S0169409X18303090
Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556146/
Jan 15, 2019 · Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin’s barrier properties prevent insulin permeation at useful levels.We investigated whether microdermabrasion ...Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
In general, it seems that a transdermal delivery system for insulin is an attractive option. Even though progress in the transdermal delivery of insulin seems promising, because of the poor permeation capacity of insulin and the high susceptibility of the skin to adverse immunological reactions, it is still doubtful whether this delivery route ...
https://professional.diabetes.org/abstract/transdermal-delivery-insulin-patients-type-1-diabetes
Transdermal Delivery of Insulin in Patients with Type 1 Diabetes A novel daily transdermal insu A novel daily transdermal insulin patch is being developed to provide basal levels of insulin in patients with type 1 or type 2 diabetes.
https://www.ondrugdelivery.com/novel-transdermal-delivery-systems-treatment-diabetes/
TRANSDERMAL INSULIN DELIVERY. Insulin is a 5,808 Da peptide that that is produced and stored in the pancreas as a hexamer (35 kDa) but active as a monomer. It is typically administered as a subcutaneous injection either as a bolus before meals or as a once or twice daily long-acting injection to achieve a basal profile.
http://drugdelivery.chbe.gatech.edu/Papers/2004/Martanto%20Pharm%20Res%202004.pdf
10 s, 10 min, or 4 h after initiating transdermal insulin delivery. Blood glucose levels were measured electrochemically every 30 min. Plasma insulin concentration was determined by radioimmunoassay at the end of most experiments. Results. Arrays of microneedles were fabricated and demonstrated to insert fully into hairless rat skin in vivo ...
https://clinicaltrials.gov/ct2/show/NCT00519623
Aug 22, 2007 · Study IN2007001 is designed to evaluate the PK/PD of the PassPort(R) Transdermal Insulin Delivery System in type 1 diabetes patients. The PK was determined by analysis of serum insulin assay values. The mean Cmax was reported.
https://www.researchgate.net/publication/275466516_Microneedles_for_transdermal_delivery_of_insulin
Transdermal delivery of insulin has been regarded as an attractive alternative owing to its easy self-administration and good patient compliance (Xie et al., 2015). To investigate the in vivo ...
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