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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
Thus, the advantages of using nanoparticles for drug delivery are a result of two main basic properties: small size and use of biodegradable materials. Nanoparticles, because of their small size, can extravasate through the endothelium in inflammatory sites, epithelium (e.g., intestinal tract and liver), tumors, or penetrate microcapillaries.Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322781/
Mar 24, 2015 · Nanoparticle drug delivery systems have found their unique applications in targeted drug delivery to tumors. While nanoparticle formulations have been successful in small animal xenograft models, their translation to clinical applications has been very rare.Author: Byung Kook Lee, Yeon Hee Yun, Kinam Park
https://www.sciencedirect.com/science/article/pii/S1319016417301792
An ideal nanoparticle drug delivery system should be able to reach, recognized, bind and deliver its load to specific pathologic tissues, and minimize or avoids drug induced damage to healthy tissues. Thus, coating specific targeting ligand(s) on the surface of nanoparticles is the most common strategy.Author: Syed A.A. Rizvi, Ayman M. Saleh
https://www.understandingnano.com/nanotechnology-drug-delivery.html
Nanotechnology and Nanoparticles in Drug Delivery. If your drug use consists of an occasional aspirin, you may not see the need for serious work on drug delivery. But if you were diabetic, having to inject insulin several times a day, or a cancer patient experiencing debilitating side …
https://drug-dev.com/nanoparticles-a-revolution-in-the-development-of-drug-delivery-vehicles/
Nanoparticles, and liposomes in particular, have been used for drug delivery in cancer and inflammatory disease therapies for several years, but traditional manufacturing methods are labor intensive, hard to reproduce, and difficult to scale up.
https://www.youtube.com/watch?v=SX-XmqINUKM
Mar 29, 2017 · This animation describes the latest research developments in nanoparticle-based cancer therapies. It explores how the technology can be used to specifically target cancer cells over healthy cells ...Author: 3D Visualisation Aesthetics Lab UNSW
https://www.hindawi.com/journals/jnm/2016/1087250/
Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones.Author: Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, Zi Chen
https://www.nature.com/articles/srep26783
May 26, 2016 · Here, by using dissipative particle dynamics simulations, we take two typical coating polymers (i.e., hydrophilic and zwitterionic polymers) as an example, and systematically investigate their effect on cellular delivery of hydrophobic and charged nanoparticles (in the presence of serum protein).Author: Hong-ming Ding, Yu-qiang Ma, Yu-qiang Ma
https://www.researchgate.net/publication/272148044_Computational_Modeling_of_Nanoparticle_Targeted_Drug_Delivery
Computational Modeling of Nanoparticle Targeted Drug Delivery Liu et al. and c s surface concentration of adsorbed species (mol/m 2 5 . Note that c s is different from c which is reflected in their
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