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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723100/
A previous study using PLGA nanoparticles as a carrier to control lovastatin release showed that this method enhanced bone repair in rats.28 In this study, a double emulsion was utilized to add a chitosan coating on PLGA nanoparticles.Author: Bor-Shiunn Lee, Chien-Chen Lee, Yi-Ping Wang, Hsiao-Jan Chen, Chern-Hsiung Lai, Wan-Ling Hsieh, Yi-W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614711/
Jul 31, 2008 · Preparation of Nifedipine Loaded Chitosan-Alginate Nanoparticles. A constant volume (300 μl) nifedipine solution in a dehydrated alcohol/water mixture (1:1, 1.105 mg/ml) was incorporated into the calcium chloride solution, then the other processes were the same as the preparation of blank chitosan-alginate nanoparticles.Author: Ping Li, Ya-Ni Dai, Jun-Ping Zhang, Ai-Qin Wang, Qin Wei
https://www.nature.com/articles/s41598-020-57666-8
Jan 22, 2020 · In this study, chitosan and alginate were selected to prepare alginate/chitosan nanoparticles to load the drug lovastatin by the ionic gelation method. The synthesized nanoparticles …Author: Hoang Thai, Chinh Thuy Nguyen, Loc Thi Thach, Mai Thi Tran, Huynh Duc Mai, Trang Thi Thu Nguyen, Gia...
https://www.ncbi.nlm.nih.gov/pubmed/31953085
Mar 15, 2020 · This study aims to formulate and optimize simvastatin loaded chitosan-tripolyphosphate nanoparticles (SIM CS-TPP NPs) using ionic gelation method to provide a local delivery system that controls and sustains the release of simvastatin in the desired dose to promote bone regeneration.Author: Wisam Khalaf Delan, Mai Zakaria, Basma Elsaadany, Aliaa N. ElMeshad, Wael Mamdouh, Ahmed R. Fares
https://www.frontiersin.org/articles/10.3389/fphar.2020.00317/full
The poor solubility and permeability of most chemotherapeutic drugs lead to unsatisfactory bioavailability combined with insufficient drug concentration. In this study, positively charged nanoparticles based on chitosan were developed and synthesized to enhance tumor penetration capability of 10-Hydroxycamptothecin (HCPT) in order to improve the chemotherapeutic effect of melanoma. The …
https://www.researchgate.net/publication/230559444_Chitosan_nanoparticles_as_a_drug_delivery_system
Chitosan nanoparticles as a drug delivery system Article (PDF Available) in Research Journal of Pharmaceutical, Biological and Chemical Sciences 1(3) · January 2010 with 2,965 Reads
https://www.sciencedirect.com/science/article/pii/S0168365913009681
Based on these findings, publications have reported the design of improved chitosan-based delivery system to bypass the polymer limitations and therefore to increase the efficiency of the carrier , , , , . In this study, we aimed at developing chitosan-based nanoparticles suitable for an intravenous administration of siRNA.Author: Héloïse Ragelle, Raphaël Riva, G. Vandermeulen, B. Naeye, Vincent Pourcelle, C. S. Le Duff, C. D'Hae...
https://www.hindawi.com/journals/apt/2020/7879368/
Another technique used for increasing the solubility of lovastatin is the solubilization of surfactant by microemulsion or self-microemulsifying drug delivery system methods. The solubility of the drug in these systems was 1.3 to 2.27 times higher than raw lovastatin [ 5 , 6 ].Author: Duc-Thuan Nghiem, Thuy-Chinh Nguyen, Minh-Thanh Do, Thi-Huyen Nguyen, Dai Lam Tran, Tran-Dung Hoang,...
https://www.sciencedirect.com/science/article/pii/S0939641112001038
In another study, the potential of thiolated chitosan for peptide delivery systems via the buccal mucosa was investigated in pigs . The therapeutic peptide PACAP was applied to pigs, and its bioavailability was determined in order to facilitate the treatment of type 2 diabetes.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Although nanoformulation is aimed at enhancing drug delivery without loss of drug activity, in a study comparing insulin-chitosan nanoparticles to chitosan solution and chitosan powder formulations the insulin-chitosan nanoparticles were less effective in terms of bioavailability and lowering blood glucose level in both a rat and sheep model (Dyer et al 2002).Author: Wim H De Jong, Paul Ja Borm
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