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http://www.pharmtech.com/achieving-zero-order-release-kinetics-using-multi-step-diffusion-based-drug-delivery
May 02, 2014 · Abstract: Zero-order release, in which a drug is released at a constant rate, is the ultimate goal of all controlled-release drug-delivery mechanisms. It leads, in principle, to the best control of plasma concentration and offers several advantages, including improved patient compliance and reduction in the frequency of drug administration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · After a decade of extensive efforts it was realized that zero-order delivery was not really necessary to develop sustained drug delivery systems. First, zero-order release does not result in maintenance of the constant drug concentration in the blood. This is particularly obvious for oral delivery systems.Author: Kinam Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269670/
Dec 22, 2011 · Controlled delivery systems that can provide zero-order drug delivery have the potential for maximizing efficacy while minimizing dose frequency and toxicity. Thus, zero-order drug release is ideal in a large area of drug delivery which has therefore led to the development of various technologies with such drug release patterns.Author: Kovanya Moodley, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M. K. Ndesendo, Pradeep ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/controlled-drug-release
10.8.5.1 Zero-Order Extravascular Drug Delivery. A number of controlled drug release approaches deliver drug at a steady rate into an extravascular region of the body. Examples include transdermal patches, implantable pumps, and intramuscular depot injections.
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
INTRODUCTION: Controlled drug delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. higher cost of controlled-release systems compared with …
https://www.hansvanlaarhoven.nl/diffusion-based-delivery/
The drug delivery from a diffusion based delivery system can be simulated using the transport of diluted species module in Comsol Multiphysics™. In order to predict how fast the drug diffuses from the active layer to a dissolution vessel or a physiological body, the compartments of the drug delivery system have to be defined in Comsol ...
https://ptfarm.pl/pub/File/Acta_Poloniae/2010/3/217.pdf
purpose of the controlled release systems is to main-tain drug concentration in the blood or in target tis-sues at a desired value as long as possible (2). In other words, they are able to exert a control on the drug release rate and duration (3). For this purpose, generally, controlled release system initially releaseFile Size: 65KB
https://www.slideshare.net/AmrutaSambrekar/rate-controlled-drug-delivery-system
Feb 10, 2013 · Rate Controlled Drug Delivery System Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website.
https://pdfs.semanticscholar.org/ec84/3d7dabecf7498324497488d784fe0f845070.pdf
Ideally, the drug should have half-life of 3-4 hours for formulation of drug delivery system [2-5]. 2.2) Therapeutic index Drugs with low therapeutic index are unsuitable for incorporation in Sustained release formulations. If the system fails in the body, dose dumping may occur, which leads to toxicity [5].File Size: 406KB
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