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https://www.sciencedirect.com/science/article/pii/S1773224717303131
Zeolitic imidazolate framework (ZIF-8) has been synthesized at room temperature in aqueous medium. Their suitability as potential drug carrier for delivery of an anti-leukemia drug, 6-mercaptopurine (6-MP) is examined. 6-MP was loaded in situ into the ZIF-8 nanoparticles during synthesis.Author: Harpreet Kaur, Girish C. Mohanta, Vandana Gupta, Deepak Kukkar, Sachin Tyagi
https://www.nature.com/articles/s41598-017-12786-6
Oct 03, 2017 · The present work enlightens a novel approach of single step fabrication of CCM-ZIF-8 as a drug carrier and its application as stimuli responsive drug delivery systems via external stimuli ...Author: Ashish Tiwari, Ashutosh Singh, Neha Garg, Jaspreet K. Randhawa
https://www.sciencedirect.com/science/article/pii/S0039914018311445
Herein, we constructed a novel hydrophobic drug delivery nanocarrier based on the RGD modified ZIF-8 for targeted and pH-responsive cancer treatment. As shown in Scheme 1, camptothecin (CPT), a representative hydrophobic anticancer drug, was encapsulated into the …Author: Kai Dong, Yan Zhang, Lu Zhang, Lu Zhang, Zhenzhen Wang, Jinsong Ren, Xiaogang Qu
https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00435
Developing multifunctional hybrid nanosystems for controlled drug delivery is a challenging task. In this work, we prepared hierarchical core–shell nanoparticles (ZnO–DOX@ZIF-8) composed of mesoporous ZnO core and microporous ZIF-8 shell, in which the core serves as the drug storage reservoir for the loading of anticancer drug doxorubicin (DOX) and the shell could be used to prevent ...Author: Cunchuan Zheng, Yang Wang, Soo Zeng Fiona Phua, Wei Qi Lim, Yanli Zhao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856809/
Oct 11, 2019 · All in all, the framework of ZIF‐8 fulfilled essential requirements for an arsenic drug delivery carrier for cancer therapy such as: a nanoparticle size, high arsenic loading, very prominent pH‐triggered release behaviour and promising results of the first in vitro experiments.Author: Romy Ettlinger, Natalia Moreno, Dirk Volkmer, Kornelius Kerl, Hana Bunzen
https://pubs.acs.org/doi/abs/10.1021/nn406590q
We have developed a general synthetic route to encapsulate small molecules in monodisperse zeolitic imid-azolate framework-8 (ZIF-8) nanospheres for drug delivery. Electron microscopy, powder X-ray diffraction, and elemental analysis show that the small-molecule-encapsulated ZIF-8 nanospheres are uniform 70 nm particles with single-crystalline structure.Author: Jia Zhuang, Chun-Hong Kuo, Lien-Yang Chou, De-Yu Liu, Eranthie Weerapana, Chia-Kuang Tsung
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801526
Nov 20, 2018 · Zou et al. 24 synthesized ZIF‐8‐coated hollow mesoporous silica NPs (HMSNs; HMSN@ZIF‐8) to produce a pH‐responsive drug delivery system. ZIF‐8 was used both as a self‐sacrificial template to synthesize the HMSNs and as a mesopore blocker grafted onto the HMSNs.
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