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https://www.drugs.com/cdi/zidovudine-injection.html
Jan 02, 2020 · Uses of Zidovudine Injection: It is used to treat HIV infection. It is used to keep the HIV infection from passing from the mother to the newborn during delivery. The newborn will also be given zidovudine injection after birth.Drug class: Nucleoside reverse transcriptase inhibitors (NRTIs)
http://ijpsr.com/bft-article/preparation-and-evaluation-of-hollow-microsphere-drug-delivery-system-of-zidovudine/?view=fulltext
Zidovudine has all the requisite characteristics suitable for developing floating drug delivery system, which includes low bioavailability, dose dependent toxicity, and its short half life. Hence, Hollow microspheres were prepared to improve the Bioavailability and decrease dosing frequency.
http://www.ajrcps.com/article/DEVELOPMENT%20OF%20GASTRO%20RETENTIVE%20FLOATING%20DRUG%20DELIVERY%20SYSTEM%20OF%20ZIDOVUDINE%20USING%20PSYLLIUM%20HUSK.pdf
The purpose of present research was to develop and evaluate gastro retentive floating drug delivery system of an antiretroviral drug Zidovudine using natural polymers. The floating tablet of Zidovudine was prepared by direct compression method (effervescent method) by using natural polymers like psyllium husk powder, guar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134651/
AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporation. The proposed system was evaluated in vitro for particle morphology, lag time and floating time, loading rate, release profile, and the release kinetic of AZT release.Author: Valquíria Miwa Hanai Yoshida, José Martins de Oliveira Junior, Marcos Moisés Gonçalves, Marta Maria ...
http://ijpsr.com/bft-article/preparation-and-evaluation-of-hollow-microsphere-drug-delivery-system-of-zidovudine/
Zidovudine is the first approved compound for the treatment of HIV; however the main limitation to therapeutic effectiveness of Zidovudine is its dose dependent toxicity, short biological half-life and poor bioavailability. Thus, to overcome the problem the gastroretentive floating drug delivery system is …
https://www.rxlist.com/retrovir-drug.htm
Jan 14, 2019 · Consistent with passive transmission of the drug across the placenta, zidovudine concentrations in neonatal plasma at birth were essentially equal to those in maternal plasma at delivery [see Use In Specific Populations].
https://aidsinfo.nih.gov/drugs/4/zidovudine/0/patient
Jan 20, 2020 · Zidovudine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the following uses: To treat HIV infection in adults and children 4 weeks of age and older. When zidovudine is used to treat HIV infection, the medicine is always used in combination with other HIV medicines.
https://www.sciencedirect.com/science/article/pii/S0974694312000187
Zidovudine is the first approved compound for the treatment of AIDS, and having short biological half-life and poor bioavailability. The present research work an attempt has been made to design the zidovudine gas powered multiple unit drug delivery system for controlled release.Author: Mohd Abdul Hadi, A. Srinivasa Rao, Srinivas Martha, Y. Sirisha, P. Udaya Chandrika
https://www.drugs.com/dosage/zidovudine.html
Oct 19, 2018 · -This drug is recommended as a component of a preferred (or alternative) 3-drug regimen for nonoccupational postexposure prophylaxis of HIV infection in children age 4 weeks to 2 years and as a component of an alternative 3-drug regimen in children age 2 to 12 years.
https://pharmacophorejournal.com/storage/models/article/cG1bD2zldr2XKpMeNXltjKsDy3MIomlPHtTuUKuJssCcBoa5MTA0yalzq12Z/floating-drug-delivery-system-a-review.pdf
Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system.File Size: 1MB
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