We have collected information about Targeted Gene Delivery for you. Follow the links to find out details on Targeted Gene Delivery.
https://www.intechopen.com/books/novel-gene-therapy-approaches/targeted-gene-delivery-importance-of-administration-routes
Various targeted gene delivery systems via the intravenous route have been developed worldwide. By intravenous administration, various organs and cells can be targeted. However, undesirable and broad biodistribution of vectors can easily lead to side effects. Adenoviral vectors have liver tropism after intravenous injection . If the target is not the liver, it is necessary to reduce hepatic transgene expression.Author: Shintaro Fumoto, Shigeru Kawakami, Mitsuru Hashida, Koyo Nishida
https://www.sciencedirect.com/science/article/pii/S0939641113002300
Targeted cyclodextrin-containing vectors equipped with lactose , mannose , folate and transferrin ligands have been studied in gene delivery. However, in all these formulations, the cyclodextrin material had to be combined with another polymer, usually PEI, to be efficient.Author: Cristina Aranda, Koldo Urbiola, Alejandro Méndez Ardoy, José M. García Fernández, Carmen Ortiz Melle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739627/
Feb 10, 2016 · Targeted Gene Transfer to the Brain via the Delivery of Brain-Penetrating DNA Nanoparticles with Focused UltrasoundAuthor: Brian P. Mead, Panagiotis Mastorakos, Panagiotis Mastorakos, Jung Soo Suk, Alexander L. Klibanov, Ju...
https://www.nature.com/articles/s41598-018-22280-2
Mar 05, 2018 · The basic concept and design, shown in Fig. 1a, can be potentially applied within a lumen and be used for targeted gene delivery. It is based on a …Author: Stephan Boehringer, Paulius Ruzgys, Paulius Ruzgys, Luca Giuseppe Athos Tamò, Saulius Šatkauskas, Th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751349/
Dec 10, 1999 · Folate conjugation, therefore, presents a potential strategy for tumor-selective targeted gene delivery. In the current study, we investigated a series of folate conjugates of the cationic polymer polyethylenimine (PEI) for potential use in gene delivery.Author: Wenjin Guo, Robert J. Lee
https://www.nature.com/articles/nmeth.2030
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins ... supporting the use of this technique in place of viral-mediated gene delivery for inducing gene knockouts in cultured ...Author: Thomas Gaj, Jing Guo, Yoshio Kato, Shannon J Sirk, Carlos F Barbas
https://www.nature.com/articles/s41596-018-0097-3
Systemic AAV vectors for widespread and targeted gene delivery in rodents. ... K. Y. et al. Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nat.
https://www.nature.com/articles/s41434-020-0144-x
Mar 26, 2020 · Directed gene therapy mediated by nucleases has become a new alternative to lead targeted integration of therapeutic genes in specific regions in the genome. In …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · The administration of the genetic material directly into the target tissue is in situ delivery. As most of the current delivery systems need no effective targeting, the way is proper.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960479/
Jul 01, 2016 · Several strategies have been developed to deliver genes to the CNS. 14 Initially AAV gene delivery to the brain relied on intraparenchymal injection(s) into brain regions affected by the considered disease (Fig. 1).This is a straightforward strategy for conditions involving a restricted brain region, such as, Parkinson's disease.Author: Michaël Hocquemiller, Laura Giersch, Mickael Audrain, Samantha Parker, Nathalie Cartier
Searching for Targeted Gene Delivery?
You can just click the links above. The data is collected for you.
