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https://www.gene.com/stories/targeted-delivery?topic=Access
Jan 13, 2020 · Targeted Delivery Making medicines more specific to their targets can reduce side effects and enhance effectiveness. Jan 13, 2020. A bispecific antibody binds two separate targets simultaneously by recognizing distinct proteins on two different cell types. For example, we are working to develop bispecific antibodies that can bind to both an ...
https://www.intechopen.com/books/novel-gene-therapy-approaches/targeted-gene-delivery-importance-of-administration-routes
3. Administration routes. Figure 1 shows a schematic representation of administration routes for targeted gene delivery. When target cells are distributed throughout the body, various administration routes can be chosen. Antigen-presenting cells such as macrophages and dendritic cells are good examples.Author: Shintaro Fumoto, Shigeru Kawakami, Mitsuru Hashida, Koyo Nishida
https://www.sbir.gov/node/326535
DESCRIPTION (provided by applicant): Sepsis is a disease with increasing morbidity and mortality that results from an uncontrolled inflammatory immune response initiated by the interaction of bacteria ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC192116/
Targeted adenovirus-mediated gene delivery to T cells via CD3. T J Wickham , G M Lee , J A Titus , G Sconocchia , T Bakács , I Kovesdi , and D M Segal GenVec, Inc., Rockville, Maryland 20852-1709, USA. [email protected]: T J Wickham, G M Lee, J A Titus, G Sconocchia, T Bakács, I Kovesdi, D M Segal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352545/
Jan 01, 2019 · Impact Statement. The M 3 RNA (microencapsulated modified messenger RNA) platform is an approach to deliver messenger RNA (mRNA) in vivo, achieving a nonintegrating and viral-free approach to gene therapy.This technology was, in this study, tested for its utility in the myocardium, providing a unique avenue for targeted gene delivery into the freshly infarcted myocardial tissue.Author: Raman Deep Singh, Matthew L. Hillestad, Christopher Livia, Mark Li, Alexey E. Alekseev, Alexey E. Al...
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901527?af=R
A Multifunctional Peptide‐Conjugated AIEgen for Efficient and Sequential Targeted Gene Delivery into the Nucleus. Dr. Yong Cheng. Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of …Author: Yong Cheng, Yong Cheng, Chunli Sun, Rui Liu, Juliang Yang, Jun Dai, Tianyou Zhai, Xiaoding Lou, Fan ...
https://engineering.virginia.edu/departments/biomedical-engineering/research/drug-and-gene-delivery
The combination of targeted drug and gene delivery with molecular imaging and systems biology provides a strong interdisciplinary foundation for the development and testing of novel targeted pharmaceuticals, as well as the revival and re-purposing of known small-molecule drugs with off-target eff
https://medicalxpress.com/news/2012-12-gene-silencing-drugs-effective-delivery.html
Dec 21, 2012 · Targeted gene silencing drugs are more than 500 times more effective with new delivery method. by Mary Ann Liebert, Inc
https://www.sbir.gov/sbirsearch/detail/335488
The application potential for this vector technology includes human gene therapy and rapid production of genetically modified animals (e.g., therapeutic protein production, agriculture improvement, more relevant disease models, etc.). This vector technology enables targeted, in-animal gene delivery using a homologous recombination mechanism.
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
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