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https://aidsinfo.nih.gov/guidelines/html/3/perinatal/180/intrapartum-antiretroviral-therapy-prophylaxis
Dec 24, 2019 · Panel's Recommendations for Intrapartum Antiretroviral Therapy/Prophylaxis; Panel's Recommendations Women should continue taking their antepartum antiretroviral therapy (ART) on schedule as much as possible during labor and before scheduled cesarean delivery (AIII).Intravenous (IV) zidovudine (ZDV):
https://www.drugs.com/dosage/zidovudine.html
Oct 19, 2018 · -During labor and delivery: 2 mg/kg IV (infused over 1 hour) followed by 1 mg/kg/hour (as a continuous IV infusion) until clamping of umbilical cord Comments:-Indication based on dosing regimen with 3 components, including antepartum and intrapartum treatment of HIV-1-infected mothers and postpartum treatment of HIV-1-exposed neonates
https://www.uptodate.com/contents/hiv-and-pregnancy-beyond-the-basics
LABOR AND DELIVERY WITH HIV. Medications during labor — The HIV drug zidovudine is given through an intravenous catheter when the woman does not have a low amount of HIV in the blood near the time of delivery, regardless of how the woman delivers. In these cases, zidovudine helps to reduce the risk of HIV transmission.
https://www.drugs.com/pregnancy/zidovudine.html
Zidovudine 100 mg orally 5 times a day was given for the duration of pregnancy. During labor, this drug was given IV, beginning with 2 mg/kg over the first hour, followed by 1 mg/kg/hour until delivery. For 6 weeks after birth, infants received 2 mg/kg orally every 6 hours, beginning at 8 to 12 hours of life.
https://clinicaltrials.gov/ct2/show/NCT00000862
Aug 31, 2001 · A Study of Zidovudine During Labor and Delivery in HIV-Infected Pregnant Women. ... There is an urgent need to establish a more practical method of delivering ZDV during labor and delivery that, at minimum, will approximate the rate of ZDV administration utilized in ACTG 082. In the future, this would enable women to start an intensive ZDV ...
https://jamanetwork.com/journals/jama/fullarticle/193773
Apr 25, 2001 · Context Zidovudine reduces maternal-infant transmission of human immunodeficiency virus 1 (HIV-1) infection by two thirds. Combination antiretroviral therapies are potentially more effective prevention.Objectives To assess the safety of perinatal lamivudine-zidovudine therapy, especially in...Author: Laurent Mandelbrot, Aline Landreau-Mascaro, Claire Rekacewicz, Alain Berrebi, Jean Louis Bénifla, Ma...
https://www.hiv.uw.edu/go/prevention/preventing-perinatal-transmission/core-concept/all
In this trial, the three-part regimen consisted of (1) oral zidovudine initiated at 14 to 34 weeks of gestation and continued throughout pregnancy for mothers with HIV, (2) intravenous zidovudine given during labor and delivery, and (3) oral zidovudine given to the newborn for 6 weeks.
https://aidsinfo.nih.gov/guidelines/html/3/perinatal/182/transmission-and-mode-of-delivery
Dec 24, 2019 · Panel's Recommendations Regarding Transmission and Mode of Delivery; Panel's Recommendations Scheduled cesarean delivery at 38 weeks gestation to minimize perinatal transmission of HIV is recommended for women with HIV RNA levels >1,000 copies/mL or unknown HIV levels near the time of delivery, irrespective of administration of antepartum antiretroviral therapy (ART) (AII).
https://wonder.cdc.gov/wonder/prevguid/m0051464/m0051464.asp
Jan 27, 2016 · Of these enrollees, 99% took at least 90% of the prescribed doses of ZDV during the antepartum period, and 99% took at least one dose during labor; 96% of study visits were kept. Baseline and delivery characteristics, protocol adherence, and adverse event rates were similar in the two trial groups. No women breastfed their infants.
http://perinatology.com/protocols/HIV1.htm
During labor,intravenous administration of ZDV in a 1-hour initial dose of 2 mg/kg body weight,followed by a continuous infusion of 1 mg/kg body weight/hour until delivery. Postpartum : Oral administration of ZDV to the newborn (ZDV syrup at 2 mg/kg body weight/dose every 6 hours) for the first 6 weeks of life,beginning at 8-12 hours after birth.
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