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http://www.thepharmajournal.com/vol1Issue12/Issue_feb_2013/1.1.pdf
ocular drug delivery systems are as follows: The ocular bioavailability must be increased from less than 1% to 15-20% of the administered dose. Most of the currently marketed ocular drugs were initially developed for non-ocular applications, hence their low or nonspecificity. So, there is a need to develop new drug candidates primarily
https://www.researchgate.net/publication/26576954_The_concept_of_ocular_inserts_as_drug_delivery_systems_An_overview
Ocular diseases require localized administration of drugs to the tissues around the ocular cavity. The existing ocular drug delivery systems are fairly primitive and inefficient. However, the design of ocular system is undergoing gradual transition from an empirical to rational basis.
https://pdfs.semanticscholar.org/f6b2/605ee988f061e3a215a9c6826cf7a92ae864.pdf
concept of ocular inserts as drug delivery system and examine the few inserts, which are available in the market or are being developed by pharmaceutical companies for drug delivery. The article discusses soluble ocular drug insert (SODI), Ocusert,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781321/
Sep 06, 2019 · Ocular drug transporters may alter drug’s efficacy and therefore, an evaluation of the interactions of new drug molecules and drug delivery systems with selected transporters is required during drug development . These ocular transporters can be divided into two major families: the solute carrier (SLC) family and the ATP-binding cassette (ABC ...Author: Eliana B. Souto, João Dias-Ferreira, Ana López-Machado, Miren Ettcheto, Amanda Cano, Antonio Camins ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket . Concentration of drug available in the precorneal …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://technicaljournalsonline.com/ijpsr/VOL%20III/IJPSR%20VOL%20III%20ISSUE%20II%20APRIL%20JUNE%202012/Article%203%20April%20June%202012.pdf
4.1 Ocular inserts: Films, erodible and non-erodible inserts, rods and shields are the most logical delivery systems aimed at remaining for a long period of time in the front of the eye. These polymeric delivery systems sustain and control drug release and thus avoid pulsed entry
https://laurentianarchitecture.ca/f81069/ocular-drug-delivery-systems-barriers-and-application-of-nanoparticulate-systems.pdf
intraocular implants as sustained release drug delivery systems have been developed to overcome the barriers to ocular applications increase absorption decrease metabolism and elimination and increase the residence time in ocular tissues and compartments ocular drug delivery systems 1 introduction ocular administration of drug
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