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https://www.ondrugdelivery.com/biodegradable-implants-sustained-intraocular-delivery-small-large-molecules/
Re-Vana Therapeutics is an ocular pharmaceuticals and drug delivery company focused on the development and commercialisation of long-acting biodegradable drug delivery platforms to treat chronic eye diseases. It is a spin-out company from the School of Pharmacy, Queens University Belfast.
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300024
Intraocular implants are controlled drug delivery systems prepared from biodegradable or non-biodegradable polymers. Generally, these are introduced into the vitreous through an incision in the ocular pars plana, which is located posterior to the lens and anterior to the retina. Despite the invasive characteristics of the implantation technique, the implants present several advantages that outweigh the inconveniences of the implantation procedure.
https://www.tandfonline.com/doi/abs/10.1517/17425247.3.2.261
Aug 12, 2014 · Drug delivery from ocular implants. Developing an intraocular drug delivery system (DDS) is urgently needed because most vitreoretinal diseases are refractory to conventional pharmacological approaches; eye drops and systemically administered drugs cannot deliver therapeutic drug concentrations into vitreoretinal tissue.Author: Tsutomu Yasukawa, Yuichiro Ogura, Hideya Kimura, Eiji Sakurai, Yasuhiko Tabata
https://www.sciencedirect.com/science/article/pii/S0169409X06001645
Thus, ocular implantable drug delivery systems are to be specifically designed and adapted to the targeted tissue or cell type, the physico-chemical properties of the active compound to be used and to the desired kinetic of intraocular release.Author: J.L. Bourges, C. Bloquel, C. Bloquel, Aurélien Thomas, Aurélien Thomas, F. Froussart, F. Froussart, ...
https://www.researchgate.net/publication/7270728_Drug_delivery_from_ocular_implants
Development of intraocular drug delivery systems (DDSs) is urgently required for the treatment of eye diseases, especially in the posterior segment of the eye (the vitreous cavity, retina, and ...
https://www.assignmentpoint.com/science/medical/intraocular-implants-for-extended-drug-delivery.html
Ocular Implants for Drug Delivery. Advances in materials science, biomedical engineering, and surgical techniques have encouraged the development of a variety of intraocular therapeutic devices. One class of intraocular devices includes implants for drug delivery, designed to improve the ability to deliver therapeutic drug levels into the eye.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781321/
Sep 06, 2019 · Ocular drug transporters may alter drug’s efficacy and therefore, an evaluation of the interactions of new drug molecules and drug delivery systems with selected transporters is required during drug development . These ocular transporters can be divided into two major families: the solute carrier (SLC) family and the ATP-binding cassette (ABC) family.Author: Eliana B. Souto, João Dias-Ferreira, Ana López-Machado, Miren Ettcheto, Amanda Cano, Antonio Camins ...
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