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https://www.ncbi.nlm.nih.gov/pubmed/22052240
Ocular gene delivery using lentiviral vectors. ... They possess distinct properties that make them particularly suitable for gene delivery in ophthalmic diseases, including high expression, consistent targeting of various post-mitotic ocular cells in vivo and a paucity of associated intraocular inflammation, all contributing to their ability to ...Author: K S Balaggan, R R Ali
https://www.nature.com/articles/gt2011153
Nov 03, 2011 · Ocular gene delivery using lentiviral vectors. ... Evaluation of EIAV based lentiviral vectors following ocular delivery in the nonhuman primate model: development of RetinoStat(R).Author: K S Balaggan, R R Ali
https://www.researchgate.net/publication/51766894_Ocular_gene_delivery_using_lentiviral_vectors
65 Many articles have been published investigating using lentiviral vectors in ocular gene therapy. Lentiviral vectors are effective for targeting RPE cells, but may not be able to transduce ...
https://www.researchgate.net/publication/226439165_Lentiviral_vectors
Ocular gene delivery using lentiviral vectors. ... We will focus on a new lentiviral vector as a recent gene transfer method and degenerative disorders of the CNS, and their related model systems. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Viral and nonviral delivery systems for gene delivery. ... There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus. ... Ocular gene delivery using lentiviral vectors. Gene ...
https://www.nature.com/articles/gt2011189
Feb 09, 2012 · Both types of vector are currently being used in clinical trials of ocular gene therapy and are reviewed in this special issue. 1, 2 Lentiviral vectors are very efficient for transducing cells in ...Author: R R Ali
http://www.cchem.berkeley.edu/schaffer/2006%20Publications/Greenberg_2006.pdf
GENE DELIVERY TO THE RETINA USING LENTIVIRAL VECTORS Kenneth P. Greenberg1,2, Edwin S. Lee2,3, David V. Schaffer2,4 and John G. Flannery1,2 1. INTRODUCTION The delivery of foreign DNA to the retina has proven to be a valuable tool for investigations of retinal disease, development, and complex cellular interactions. ToAuthor: Kenneth P. Greenberg, Edwin S. Lee, David V. Schaffer, John G. Flannery
https://blog.addgene.org/aavs-in-retinal-gene-therapy
Jul 31, 2018 · A better vector for ocular gene therapy: Adeno-Associated Virus (AAV) While other viral vectors such as adenovirus (AdV) and lentivirus (LV) are known to transduce retinal cells, AAV quickly became the vector of choice for ocular gene therapy. AdV and LV have been used successfully in preclinical and clinical settings for ocular conditions.
https://www.retinalphysician.com/issues/2020/special-edition-2020/vector-considerations-for-ocular-gene-therapy
Broadly speaking, gene therapy for ocular disorders requires consideration of 4 interrelated components: (1) the vector, (2) the route of delivery, (3) the specific transgene, and (4) manufacturing. 1 In the early 1990s, replication-defective retroviruses were used as the earliest gene-delivery vectors. However, genotoxicity from and ...
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