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https://www.nature.com/articles/nature10358?error=cookies_not_supported&code=b51c2e86-c7a1-4a18-a1ca-b856109e5dff
Aug 31, 2011 · We hypothesized that a poxvirus, which evolved for blood-borne systemic spread in mammals, could be engineered for cancer-selective replication and used as …Author: Caroline J. Breitbach, James Burke, Derek Jonker, Derek Jonker, Joe Stephenson, Andrew R. Haas, Laur...
https://www.ncbi.nlm.nih.gov/pubmed/21886163
Aug 31, 2011 · Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Breitbach CJ(1), Burke J, Jonker D, Stephenson J, Haas AR, Chow LQ, Nieva J, Hwang TH, Moon A, Patt R, Pelusio A, Le Boeuf F, Burns J, Evgin L, De Silva N, Cvancic S, Robertson T, Je JE, Lee YS, Parato K, Diallo JS, Fenster A, Daneshmand M, Bell JC, Kirn DH.Author: Caroline J. Breitbach, James Burke, Derek Jonker, Derek Jonker, Joe Stephenson, Andrew R. Haas, Laur...
https://www.researchgate.net/profile/Jorge_Nieva/publication/51610875_Intravenous_delivery_of_a_multi-mechanistic_cancer-targeted_oncolytic_poxvirus_in_humans/links/53d90e1b0cf2e38c6331e268.pdf?inViewer=true&pdfJsDownload=true&disableCoverPage=true&origin=publication_detail
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans Caroline J. Breitbach 1 , James Burke 2 {, Derek Jonker 3,4 , Joe Stephenson 5 , Andrew R. Haas 6 , Laura Q ...
https://www.researchgate.net/publication/51610875_Intravenous_delivery_of_a_multi-mechanistic_cancer-targeted_oncolytic_poxvirus_in_humans
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans ... used as a vehicle for the intravenous delivery and expression of transgenes in tumours. ... products in ...
http://adsabs.harvard.edu/abs/2011Natur.477...99B
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans: Authors: ... could be engineered for cancer-selective replication and used as a vehicle for the intravenous delivery and expression of transgenes in tumours. JX-594 is an oncolytic poxvirus engineered for replication, transgene expression and amplification ...
http://www.syndegen.com/files/doc/rlbd_BreitbachCJ.pdf
and used as a vehicle for the intravenous delivery and expression of transgenes in tumours. JX-594 is an oncolytic poxvirus engineered for replication plus transgene expression and amplification in cancer cells harboring activation of the Epidermal Growth Factor Receptor/ Ras pathway, followed by cell lysis and anti-cancer immunity1. In this ...
https://www.prnewswire.com/news-releases/jennerex-publishes-clinical-data-in-journal-nature-demonstrating-intravenous-delivery-of-multi-mechanistic-cancer-targeted-oncolytic-poxvirus-jx-594-to-tumors-128820008.html
Jennerex Publishes Clinical Data in Journal, Nature, Demonstrating Intravenous Delivery of Multi-Mechanistic Cancer-Targeted Oncolytic Poxvirus JX-594 to Tumors News provided by Jennerex, Inc.
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30280-5
Sep 01, 2015 · Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer. Se Hoon Park * Author Footnotes ... Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. ... Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in ...Author: Se Hoon Park, Caroline J Breitbach, Jeeyun Lee, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Anne Moon, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084676/
Sep 09, 2016 · Oncolytic virus therapy has recently been recognized as a promising new therapeutic approach for cancer treatment. An oncolytic virus is defined as a genetically engineered or naturally occurring virus that can selectively replicate in and kill cancer cells without harming the normal tissues.Author: Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30126-X
Transient pharmacological inhibition of the PI3 kinase δ isoform using CAL-101 allows for improved vaccinia virus accumulation in tumor tissues after intravenous delivery by preventing macrophage uptake of the virus. This platform allows for effective anti-tumor activity after …Author: Mark S. Ferguson, Louisa S. Chard Dunmall, Rathi Gangeswaran, Giulia Marelli, James R. Tysome, James...
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