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https://www.sciencedirect.com/science/article/pii/S0142961201000527
Results from intracellular delivery of the two labeled phospholipids, RR and PC*, indicate that the ethosomal components themselves may penetrate the fibroblasts. Both probes were found throughout the cell structure, in the membrane and the cytoplasm.Author: E. Touitou, Biana Godin, N. Dayan, C. Weiss, A. Piliponsky, F. Levi-Schaffer
https://www.ncbi.nlm.nih.gov/pubmed/11575480
The intracellular presence of each of the three probes tested, was evident after 3 min of incubation. Furthermore, with ethosomal D-289, fluorescence was also seen in the fibroblast nucleus. Enhanced delivery of molecules from the ethosomal carrier was also observed in permeation experiments with the hydrophilic calcein and lypophilic RR to whole nude mouse skin.Author: E. Touitou, Biana Godin, N. Dayan, C. Weiss, A. Piliponsky, F. Levi-Schaffer
https://scholars.houstonmethodist.org/en/publications/intracellular-delivery-mediated-by-an-ethosomal-carrier(cb65e321-585c-431f-86a1-84b2af55bbc4).html
The intracellular presence of each of the three probes tested, was evident after 3min of incubation. Furthermore, with ethosomal D-289, fluorescence was also seen in the fibroblast nucleus.Enhanced delivery of molecules from the ethosomal carrier was also observed in permeation experiments with the hydrophilic calcein and lypophilic RR to whole nude mouse skin.Author: E. Touitou, Biana Godin, N. Dayan, C. Weiss, A. Piliponsky, F. Levi-Schaffer
https://www.researchgate.net/publication/11773860_Intracellular_delivery_mediated_by_ethosomal_carrier
Furthermore, the ethosomal carrier is also able to provide an effective intracellular delivery of both hydrophilic and lipophilic molecules [10]. The proposed mechanism of skin penetration ...
https://www.deepdyve.com/lp/elsevier/intracellular-delivery-mediated-by-an-ethosomal-carrier-1bllzoNKVU
Nov 15, 2001 · Furthermore, with ethosomal D-289, fluorescence was also seen in the fibroblast nucleus. Enhanced delivery of molecules from the ethosomal carrier was also observed in permeation experiments with the hydrophilic calcein and lypophilic RR to whole nude mouse skin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116302/
Further transdermal delivery system for cannabidiol by using ethosomal carrier was also designed by Lodzki and colleagues (2003). Again Godin and Touitou (2004) investigated the dermal and intracellular delivery of bacitracin from ethosomes. After that Elasayed et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255417/
Ethosomes offers a good opportunity for the non-invasive delivery of small-, medium-, and large-sized drug molecules. The results of the first clinical study of the acyclovir-ethosomal formulation support this conclusion. Studies will continue to further improve the skin delivery of drugs using lipid vesicles.
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