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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849913/
Apr 05, 2010 · Characterization of Intracellular Peptide Delivery in HeLa cells. The potential of poly[HPMA]-b-[(PAA)(BMA)(DMAEMA)] as a peptide intracellular delivery vehicle was investigated following bioconjugation to the Bak-BH3 peptide fused with the Antp (also known as penetratin) PTD.Author: Craig L. Duvall, Anthony J. Convertine, Danielle S. W. Benoit, Allan S. Hoffman, Patrick S. Stayton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076797/
Mar 01, 2011 · The caspase and L78A peptide results demonstrate that the delivered BH3 is indeed working through the biologically relevant apoptosis signaling pathway. These studies establish the ability of PPAA to strongly enhance the intracellular delivery of a functional pro-apoptotic peptide.Author: Brian Albarran, Allan S. Hoffman, Patrick S. Stayton
https://pubs.acs.org/doi/10.1021/mp9002267
Dec 07, 2009 · These results indicate that this multifunctional carrier shows significant promise for proapoptotic peptide cancer therapeutics and also as a general platform for delivery of peptide drugs with intracellular targets.Author: Craig L. Duvall, Anthony J. Convertine, Danielle S. W. Benoit, Allan S. Hoffman, Patrick S. Stayton
https://www.sciencedirect.com/science/article/pii/S1381514810001665
The caspase and L78A peptide results demonstrate that the delivered BH3 is indeed working through the biologically relevant apoptosis signaling pathway. These studies establish the ability of PPAA to strongly enhance the intracellular delivery of a functional pro-apoptotic peptide.Author: Brian Albarran, Allan S. Hoffman, Patrick S. Stayton
https://www.nature.com/articles/s41598-018-30790-2
Aug 22, 2018 · Intracellular delivery of the proapoptotic peptide PAP 37 has been shown to directly induce dose-dependent apoptotic cell death 38. Each Phylomer CPP was synthesized as a SpyTag fusion (CPP_SpyT ...Author: Katrin Hoffmann, Nadia Milech, Suzy M. Juraja, Paula T. Cunningham, Shane R. Stone, Richard W. Franc...
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00250
We have sought to investigate the promising potential of this peptide as an intracellular delivery vehicle directed to EGFR-positive cells. The selectivity of peptide 1 to the EGFR was confirmed by a positive correlation between the expression level of the receptor and the cellular uptake of peptide 1 as shown by siRNA knockdown of the EGFR.Author: Kei Toyama, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes current approaches to the intracellular delivery of protein and peptide drugs.Author: Vladimir Torchilin
https://www.pnas.org/content/110/40/15919
Oct 01, 2013 · Using a peptide library selection strategy, we identified a sequence, called M2pep, that preferentially binds to anti-inflammatory murine macrophages. We then used M2pep to carry a proapoptotic peptide to TAMs by i.v. delivery and demonstrated that selective reduction of TAMs resulted in improved survival in tumor-bearing mice.Author: Maryelise Cieslewicz, Jingjing Tang, Jonathan L. Yu, Hua Cao, Maja Zavaljevski, Koka Motoyama, Andre...
https://www.researchgate.net/publication/40455240_Intracellular_Delivery_of_a_Proapoptotic_Peptide_via_Conjugation_to_a_RAFT_Synthesized_Endosomolytic_Polymer
Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized Endosomolytic Polymer Article in Molecular Pharmaceutics 7(2):468-76 · December 2009 with 66 Reads
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)30115-0.pdf
Intracellular Delivery System for Antibody–Drug Conjugates copolymer with both targeting and intracellular peptide delivery capabilities. The first block of the polymer was designed to con-jugate CD22-targeting monoclonal antibodies-linked to streptavi-din (αCD22) and the …
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