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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Targeted intracellular delivery of antibodies can be aimed at the antigens localized in various intracellular compartments, predominantly the ER, cytosol, and nucleus. Examples of efficient antibody intracellular delivery approaches aimed at specified intracellular compartments are presented in …Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201705578
Antibodies are important biopharmaceuticals, but almost all existing antibody‐based drugs are limited to targeting antigens located at the cell exterior because of the inability of antibodies to enter the cell interior. Available methods for intracellular delivery of antibodies have major shortcomings.Author: Peiyan Yuan, Hailong Zhang, Linghui Qian, Xin Mao, Shubo Du, Changmin Yu, Bo Peng, Shao Q. Yao
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · This study provides a solid basis for further exploration of therapeutic antibodies for intracellular targets. Intracellular delivery of therapeutic antibodies into specific cells using antibody ...Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764859/
The therapeutic potential of antibodies has not been fully exploited as they fail to cross cell membrane. In this article, we have tested the possibility of using plant virus based nanoparticles for intracellular delivery of antibodies. For this purpose, ...Author: Ambily Abraham, Usha Natraj, Anjali A. Karande, Ashutosh Gulati, Mathur R. N. Murthy, Sathyabalan Mu...
https://www.nature.com/articles/ncomms12277
Jul 22, 2016 · Intracellular proteins have been identified for their potential as biopharmaceutical drugs; however, many of the challenges associated with intracellular protein delivery have yet to be solved 1.Author: Nambin Yim, Seung Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, ...
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b01335
Direct intracellular delivery of antibodies has gained much attention, although only a few agents have been developed, and none of them has reached clinical stages. The main obstacles here are the insufficient characteristics of delivery systems including stability and appropriate ability for intracellular antibody release.Author: Ahram Kim, Yutaka Miura, Takehiko Ishii, Omer F. Mutaf, Nobuhiro Nishiyama, Horacio Cabral, Kazunori...
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