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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Examples of efficient antibody intracellular delivery approaches aimed at specified intracellular compartments are presented in Table Table4, 4, and the advantages and limitations of different approaches are summarized in Table Table5. 5. The ER is very easily targeted by intrabodies, as natural antibodies already contain a signal for secretion ...Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.frontiersin.org/articles/10.3389/fphar.2018.01208/full
Oct 24, 2018 · Another theme that emerges from the intracellular antibody delivery concept is the ability to relocate protein-of-interest within the cells or deplete it through a cellular protein elimination system. Protein relocation is an approach to interfere with target protein function through trapping it with binder molecule and thereby preventing the ...Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions Skip to main content Thank you for visiting nature.com.Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427876/
Antibodies armed with biologic drugs could greatly expand the therapeutic potential of antibody–drug conjugates for cancer therapy, broadening their application to disease targets currently limited by intracellular delivery barriers.Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
https://clincancerres.aacrjournals.org/content/25/15/4846
Aug 01, 2019 · Experimental Design: We have developed a new targeted nanomedicine based on hyaluronic acid–biocompatible nanocapsules, which allow the intracellular delivery of a specific anti-GSDMB antibody into HER2 breast cancer cells both in vitro and in vivo.Author: Ángela Molina-Crespo, Ana Cadete, David Sarrio, Manuel Gámez-Chiachio, Lidia Martinez, Kinlin Chao, ...
https://www.nature.com/articles/nchem.2779
May 22, 2017 · One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report …Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.researchgate.net/publication/328484032_Targeted_Intracellular_Delivery_of_Antibodies_The_State_of_the_Art
to enhance intracellular antibody delivery, which has led to. cell penetrating TransMabs (Muller et al., 2005) or transbodies. An early study (Anderson et al., 1993), revealing enhanced cell.
https://www.sciencedirect.com/science/article/pii/S0165247802001463
3.2. Intracellular delivery of monoclonal anti-Gag antibody. All of the antibodies were tested on all cell lines for cellular penetration prior to modification. With one exception, 3B3, no staining was seen. The fields were essentially blank, i.e not even surface binding could be seen.Author: Bi-Xing Chen, Bernard F Erlanger
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01001/full
Aug 18, 2017 · Intracellular Antibodies. Intracellular antibodies, which may also be called intrabodies, are antibodies that are produced in the cell, and bind an antigen within the same cell. This is a different delivery strategy from antibodies that are produced extracellularly, and are engineered to then penetrate the cell to access their intracellular target.Author: Iva Trenevska, Demin Li, Alison H. Banham
https://www.sciencedirect.com/science/article/pii/S0168365916307519
The intracellular delivery mediated by the Hex nanocarrier was found to be specific for antibody since other proteins, including BSA and recoverin, did not result in cellular fluorescence in the presence of the Hex nanocarrier (Supplementary Fig. S7). A recent example of intracellular delivery of functional antibodies utilized VLPs as a core .Author: Sung In Lim, Cyril I. Lukianov, Julie A. Champion
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