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https://www.nature.com/articles/nature05901
Jun 17, 2007 · Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide ...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.sciencedirect.com/topics/neuroscience/small-interfering-rna
Small interfering RNA (siRNA), with length in 20–25 bp, is a short double-stranded RNA molecule. siRNA has been recognized as a promising therapeutic for antiviral, anticancer, or other genetic diseases (Li & Huang, 2006; Xue, Liu, & Wong, 2014; Zhao, Mi, & Feng, 2013). Currently, biomedical application of siRNA is still limited due to the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202607/
May 01, 2010 · RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, we report on a novel approach to overcome these limitations using a multistage vector composed of mesoporous silicon particles (stage 1 ...Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700756/
To facilitate the cost-effective production of interfering RNA and delivery of RNA pesticides to mosquitoes in the field, S. cerevisiae was engineered to produce shRNA corresponding to select genes/target sequences identified in the siRNA larvicide screens [9, 10] (Table 1 1).Author: Molly Duman-Scheel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.
https://www.sciencedirect.com/science/article/pii/B9780128001486000043
The discovery of RNA interference (RNAi) in mammalian cells has created a new class of therapeutics based on the reversible silencing of specific disease-causing genes. This therapeutic potential depends on the ability to deliver inducers of RNAi, such as short-interfering RNA (siRNA) and micro-RNA (miRNA), to cells of target tissues.Author: Alex K.K. Leung, Yuen Yi C. Tam, Pieter R. Cullis
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Delivery materials. Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo []—however, this section will focus mainly on the development of non-viral materials (Table 1).Of the non-viral RNA delivery vehicles, nanoparticles …Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://advances.sciencemag.org/content/5/9/eaaw6499.full
Sep 01, 2019 · RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)–assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacting protein kinase 4 ( RIPK4 ) efficiently silenced its expression to …Author: Jianye Liu, Yi Zhang, Qinghai Zeng, Hongliang Zeng, Xiaoming Liu, Pei Wu, Hongyi Xie, Leye He, Zhi L...
https://link.springer.com/article/10.1007%2Fs12274-017-1946-z
Aug 02, 2018 · We report the development of a small interfering RNA (siRNA) delivery vector based on cationic perfluorocarbon nanoemulsions. We have prepared perfluorodec The fluorinated emulsion (F-PEI@PFD) reduced cytotoxicity of F-PEI and demonstrated effective binding with siRNAs to form nanosized emulsion polyplexes.Author: Gang Chen, Kaikai Wang, Pengkai Wu, Yixin Wang, Zhanwei Zhou, Lifang Yin, Minjie Sun, David Oupický,...
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