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https://www.nejm.org/doi/full/10.1056/NEJM200005183422007
Preterm delivery is the chief problem in obstetrics today, accounting for 70 percent of perinatal mortality and nearly half of long-term neurologic morbidity. 1 , 2 Approximately 10 percent of all births are preterm, but most of the serious illness and death is concentrated in the 1 to 2 percent of infants who are born at less than 32 weeks of ...Author: Robert L. Goldenberg, John C. Hauth, William W. Andrews
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249583/
Dec 01, 2014 · Goldenberg et al. suggest that the 25–40% of preterm deliveries ascribed to intrauterine infection may be a minimum estimate due to potential culture and sample selection bias . Similarly, histologic chorioamnionitis, a hallmark of intrauterine infection, has been reported in nearly 70% of preterm deliveries between 20 and 24 weeks’ gestational age, but in only 16% of cases delivered …Author: Matthew W. Kemp
https://www.researchgate.net/publication/12502140_Intrauterine_Infection_And_Preterm_Delivery
Ascending intrauterine infection/inflammation (AIUI) is a central pathophysiology of spontaneous preterm birth due to either preterm labor and intact membranes (PTL) or preterm premature rupture ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380388/
Intrauterine infection and why preterm prevention programs have failed. ... Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obstet Gynecol. 1992 May ... Andrews WW, Goldenberg RL, Hauth JC. Preterm labor: emerging role of genital tract infections. Infect Agents Dis. 1995 Dec ...Author: R L Goldenberg, W W Andrews
https://www.semanticscholar.org/paper/INTRAUTERINE-INFECTION-AND-PRETERM-DELIVERY-Obert-G/6f2d5ab2118006747d919e8f7fa2396ae14816b8
That preterm delivery may occur in association with leukocytosis of the amniotic fluid or chorioamnion has long been recognized. 6,7 However, the first substantial microbiologic evidence relating intrauterine infection before membrane rupture to preterm delivery was presented only in the late 1970s, when P bacteria were cultured from the amniotic fluid of 7 of 10 women in preterm labor who had intact …
https://www.sciencedirect.com/science/article/pii/S1744165X1500147X
In the Vaginal Infections and Prematurity Study, infection with T. vaginalis in a pregnant population was associated with a 30% higher risk of delivering an infant with low birth weight (LBW) or preterm, a 40% higher risk of giving birth to an infant who was both preterm and LBW, and nearly twice the risk of stillbirth or neonatal death, as compared with women without T. vaginalis colonization .Author: Hugh C.G. Nadeau, Akila Subramaniam, William W. Andrews
https://www.frontiersin.org/articles/10.3389/fimmu.2014.00574/full
Preterm birth (PTB) (delivery before 37 weeks’ gestation) is a leading cause of neonatal death and disease in industrialized and developing countries alike. Infection (most notably in high-risk deliveries occurring before 28 weeks’ gestation) is hypothesized to initiate an intrauterine inflammatory response that plays a key role in the premature initiation of labor as well as a host of the ...Author: Matthew W. Kemp
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242863/
At least 40% of preterm births are associated with intrauterine infection. 3 In individual cases it is often difficult to determine whether infection is the cause or consequence of the processes leading to preterm delivery. However, there is abundant evidence that infection and the inflammation generated by infection, whether within the gestational tissues or elsewhere, are a primary cause of a substantial proportion of preterm births.Author: Varkha Agrawal, Emmet Hirsch, Emmet Hirsch
https://www.researchgate.net/publication/316319024_Intrauterine_infection_immune_system_and_premature_birth
Apr 20, 2017 · Intrauterine infection, immune system and premature birth. Preterm birth accounts for nearly one million deaths among children under five years of age, and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection and fetal inflammatory response …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962114/
Instead, bacterial infections may cause stillbirth by precipitating preterm labor, and perhaps intrauterine bleeding, with the fetus dying in relationship to one of those conditions. Placental damage, including thrombosis, resulting from these infections also may cause decreased oxygenation, resulting in stillbirth by that mechanism.Author: Elizabeth M. McClure, Robert L. Goldenberg
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