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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430346/
Jun 10, 2015 · Pharmacological inhibitors are often used to study intracellular trafficking mechanisms of drug and gene delivery vectors (Table 1). These inhibitors are also typically toxic beyond certain concentrations and could potentially inhibit the transgene expression via non-specific mechanisms .Author: Rahul K. Keswani, Mihael Lazebnik, Daniel W. Pack
https://www.sciencedirect.com/science/article/pii/S092809871730619X
3.2. Intracellular Trafficking of Protein-DNA Nanoparticles. Previous confocal microscopy images obtained for T-Rp3-DNA internalization gave indications that it could accumulate in the perinuclear region, in a pattern that differs from that of other delivery proteins, such as protamine (Favaro et al., 2014).However, the mechanisms involved in promoting this difference had not been elucidated.Author: Marianna Teixeira de Pinho Favaro, Marianna Teixeira de Pinho Favaro, Ugutz Unzueta, Martí de Cabo, ...
https://www.sciencedirect.com/science/article/pii/S0168365915002333
Hybrid vectors represent a promising new generation of efficient gene delivery agents. The elucidation of their intracellular trafficking process within the cell provides further evidence that viruses or virus-like particles can have significantly different interactions with …Author: Rahul K. Keswani, Mihael Lazebnik, Daniel W. Pack
https://www.ncbi.nlm.nih.gov/pubmed/16507881
In this article, we review the different uptake pathways that are involved in nonviral gene delivery from a gene delivery point of view. In addition, available knowledge concerning cellular entry and the intracellular trafficking of cationic lipid-DNA complexes (lipoplexes) and cationic polymer-DNA complexes (polyplexes) is summarized. PMID ...Author: Ikramy A. Khalil, Kentaro Kogure, Hidetaka Akita, Hideyoshi Harashima
https://www.researchgate.net/publication/275050441_Intracellular_Trafficking_of_Hybrid_Gene_Delivery_Vectors
Non-viral gene delivery to skeletal muscle was one of the first applications of gene therapy that went into the clinic, mainly because skeletal muscle is an easily accessible tissue for local gene ...
https://www.nature.com/articles/3302592
Aug 04, 2005 · Here, we will review nonviral vector trafficking pathways, which will be considered here as the steps from cell binding to nuclear delivery. Studies on the intracellular trafficking of nonviral ...Author: L K Medina-Kauwe, L K Medina-Kauwe, J Xie, S Hamm-Alvarez
http://pharmrev.aspetjournals.org/content/58/1/32
Mar 01, 2006 · In this article, we review the different uptake pathways that are involved in nonviral gene delivery from a gene delivery point of view. In addition, available knowledge concerning cellular entry and the intracellular trafficking of cationic lipid-DNA complexes (lipoplexes) and cationic polymer-DNA complexes (polyplexes) is summarized.
https://pdfs.semanticscholar.org/1c19/9694353df34feaaaf8df2f647177364ee5ff.pdf
viral gene delivery from a gene delivery point of view. In addition, available knowledge concerning cellular entry and the intracellular trafficking of cationic lipid-DNA complexes (lipoplexes) and cationic polymer-DNA com-plexes (polyplexes) is summarized.
https://www.nature.com/articles/s41467-020-14527-2
Feb 20, 2020 · The absence of NPC1 led to enhanced retention of nucleic acids in late endosomes/lysosomes, which translated into improved cytosolic delivery. Furthermore, the intracellular trafficking of C-24 ...Author: Siddharth Patel, N. Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph P. Griffith, Shangguo ...
https://www.intechopen.com/books/novel-gene-therapy-approaches/extracellular-and-intracellular-barriers-to-non-viral-gene-transfer
To maximize non-viral gene delivery, levels of expression must be improved. Unfortunately, many extracellular and intracellular barriers (including the extracellular environment, immune scavengers, the cell membrane, endosomal escape, the cytoskeletal network and the nuclear membrane) preclude efficient gene transfer.Author: Lynn F. Gottfried, David A. Dean
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