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https://www.researchgate.net/publication/51815471_Nanoparticles_for_intracellular-targeted_drug_delivery
Nanoparticles for intracellular-targeted drug delivery. ... in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intracellular-drug-delivery
Intracellular drug delivery for most purposes is hampered by problems related to the efficacy of delivery as well as to endocytotic processing and degradation. Numerous attempts have been made to develop an efficient intracellular drug and DNA delivery system bypassing the endocytotic pathway.
https://iopscience.iop.org/article/10.1088/0957-4484/22/49/494002/pdf
Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell activity. Herein, we review the latest advances in the intracellular-targeted delivery of short interference RNA, proteins and small molecules using NPs.Author: Cristiana S O Paulo, Ricardo Pires das Neves, Lino S Ferreira
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755874/
Aug 01, 2012 · Moreover, localization signal sequences for many intracellular organelles such as lysosomes, peroxisomes, or mitochondria, as well as other nuclear localization signals, can replace the SV40 T-NLS for targeted drug delivery to one or more of the intracellular compartments of the cell.Author: Hetal Pandya, Waldemar Debinski
https://www.ncbi.nlm.nih.gov/pubmed/26675221
Also, better knowledge of non-classical endocytic pathways may help optimize targeted drug delivery systems for intracellular delivery. Therefore, this review focuses on mechanisms of intracellular delivery, including direct internalization and endocytosis, as well as factors such as targeting moiety, target receptor, and size, shape, and ...Author: Carmen Garnacho
https://pubs.acs.org/doi/10.1021/acsami.5b04684
In this work, a novel type of pH-sensitive multifunctional envelope-type mesoporous silica nanocontainers (SBDAPF) was constructed for targeted drug delivery to cancer cells. Poly(N-succinimidyl acrylate) was coated on the mesoporous silica nanoparticles surface via an acid-labile acetal linker to obtain the SBA particles for pH-triggered drug release. A model drug doxorubicin (DOX)-loaded SBA ...Author: Ke Yang, Huaiqing Luo, Ming Zeng, Yinyan Jiang, Jianming Li, Xinling Fu
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-delivery-vehicle
In various stages of development are antibody immunoliposomes with the goal of cell-specific targeted drug delivery (45). Intracellular delivery and effective cellular uptake represent major challenges to the widespread use of RNAi in vivo due to the high-molecular-weight and negative charge of siRNA duplexes.
https://www.medcraveonline.com/PPIJ/review-on-targeted-drug-delivery-against-intracellular-pathogen.html
Targeted drug delivery into the cell compartment that is the most vulnerable to effects of the corresponding drug is a challenging problem, and its successful solution can significantly increase the efficiency and reduce side effects of the delivered therapeutic agents. The current technologies for increasing of bioavailability of antibiotics by means of liposomes or nano particles.
https://www.nature.com/articles/s41598-020-61586-y
Mar 13, 2020 · Self-Propelling Targeted Magneto-Nanobots for Deep Tumor Penetration and pH-Responsive Intracellular Drug Delivery. ... such as refinements in …Author: Saloni S. Andhari, Ravindra D. Wavhale, Kshama D. Dhobale, Bhausaheb V. Tawade, Govind P. Chate, Yuv...
https://www.researchgate.net/publication/328484032_Targeted_Intracellular_Delivery_of_Antibodies_The_State_of_the_Art
Targeted Intracellular Delivery of Antibodies: The State of the Art. Article ... First established in the 1950s, the drug delivery field has since grown substantially and evolved.
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