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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151968/
Oct 16, 2007 · Furthermore, intracellular delivery of recombinant proteins to live cells offers a powerful alternative to gene or siRNA transfections. For such technology to be successful, the delivered protein needs to cross the plasma membrane and to be efficiently released in the cytoplasm.Author: Claire O. Weill, Stéphanie Biri, Abdennaji Adib, Patrick Erbacher
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763210/
Aug 22, 2018 · Expanding Protein Therapeutics Through Intracellular Delivery Since the advent of human recombinant insulin in 1982, the number of protein therapeutics has been growing rapidly 207 . There now more than 200 approved protein therapeutics, of which around half …Author: Martin P. Stewart, Martin P. Stewart, Robert Langer, Klavs F. Jensen
https://www.sciencedirect.com/science/article/pii/S0958166917302185
Another strategy for the intracellular delivery of TFs is to tether proteins to protein transduction domains (PTDs) such as TAT, ANTP and VP22, which can potentially cross biological membranes efficiently . For example, a fusion protein composed of the TAT peptide fused with a zinc finger protein targeting the SV40 promoter, and the KRAB transcriptional repression domain has been developed.Author: Yumiao Zhang, Joachim Justad Røise, Kunwoo Lee, Jie Li, Niren Murthy
http://www.ldbiopharma.com/document/technical/intracellular.pdf
Intracellular delivery of protein and peptide therapeutics Vladimir Torchilin Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA Many proteins and peptides are used as highly specific andeffectivetherapeuticagents.Theiruseis ...
https://drug-dev.com/intrabody-delivery-the-feldan-shuttle-technology-a-peptide-based-method-to-deliver-antibodies/
The direct delivery of intrabodies as proteins could become therapeutically interesting to specifically target signaling cascade components and to mediate instantaneous biological effects. 5 However, the lack of safe and robust protein delivery protocols slows down the transfer of intrabodies toward widespread clinical use. 5,7 In this review, we present the Feldan Shuttle technology, a peptide-based delivery method, that could provide the efficient and safe intrabody delivery …
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Traditional methods of intracellular delivery, such as electroporation or microinjection are invasive and applicable for in vitro experiments, but not for clinical conditions. The use of various pharmaceutical nanocarriers, such as liposomes, possessing pH-sensitivity and being able to escape from the endosomes upon the endocytic uptake, or the modification of peptide and protein drugs with cell-penetrating peptides, can allow for efficient and non-invasive intracellular delivery.Author: Vladimir Torchilin
http://www.nature.com/articles/nnano.2009.341
Nov 22, 2009 · We report a novel intracellular delivery platform based on nanocapsules that consist of a single-protein core and thin polymer shell anchored covalently to the protein core…
https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · iTOP enables the intracellular delivery of macromolecules iTOP allows the highly efficient transduction of native proteins This protein transduction is independent of a transduction peptide sequence iTOP mediates efficient manipulation of a wide variety of primary cell typesAuthor: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.ntranstechnologies.com/technology/
The iTOP intracellular delivery technology is based on a combination of small molecule compounds which forces the uptake of large gulps of extracellular fluid (containing the bioactive molecules) by the cell (D’Astolfo et al. 2015, Cell 161: 674-690).. Once inside, the vesicles release their content into the cytoplasm, where the bioactive molecules can exert their therapeutic action.
https://www.sciencedirect.com/science/article/pii/S0168365915301802
However, the use of VLPs for intracellular protein delivery requires further evaluation of immunogenicity and safety by in vivo and clinical studies. Genetic fusion with zinc-finger motifs has recently been demonstrated as an intracellular delivery technology [51] .Author: Mikyung Yu, Jun Wu, Jinjun Shi, Omid C. Farokhzad, Omid C. Farokhzad
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