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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427876/
Broadening the intracellular target space by more effective delivery of protein/peptide drugs could expand the repertoire of antibody–drug conjugates to currently undruggable disease-specific targets and permit tailored drug strategies to stratified subpopulations and personalized medicines. ... intracellular delivery system for peptides ...Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
http://www.jbc.org/content/276/37/35103.long
Sep 14, 2001 · The protein delivery system is fast and under optimal conditions displays no significant toxicity. TFA-DODAPL:DOPE, called BioPORTER, has advantages over the other protein delivery approaches, which use membrane transport peptides such as PTD since it does not require any modification of the protein to be delivered.Author: Olivier Zelphati
https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Modulation of protein function is used to intervene in cellular processes but is often done indirectly by means of introducing DNA or mRNA encoding the effector protein. Thus far, direct intracellular delivery of proteins has remained challenging.Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intracellular-drug-delivery
Intracellular drug delivery for most purposes is hampered by problems related to the efficacy of delivery as well as to endocytotic processing and degradation. Numerous attempts have been made to develop an efficient intracellular drug and DNA delivery system bypassing the endocytotic pathway.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166028/
Sep 17, 2014 · Introduction. Protein delivery has important applications both in vitro and in vivo.In vitro, delivery of proteins into cells provides a potentially game-changing approach to manipulate signaling pathways, 1 stimulate potent antitumor immune cells, 2 and induce pluripotency for tissue engineering and wound healing. 3 Effective in vivo protein delivery would provide therapeutic replacement of ...Author: Ailing Fu, Rui Tang, Joseph Hardie, Michelle E. Farkas, Vincent M. Rotello
https://www.sciencedirect.com/science/article/pii/S0958166917302185
Protein therapeutics that function inside of cells: an emerging class of therapeutics. Overview of the four major applications of intracellular protein delivery: vaccine development, transcription factor therapy, gene editing and cancer therapy. Schematic diagram describing intracellular protein delivery.Author: Yumiao Zhang, Joachim Justad Røise, Kunwoo Lee, Jie Li, Niren Murthy
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)30115-0.pdf
Intracellular Delivery System for Antibody–Drug Conjugates copolymer with both targeting and intracellular peptide delivery capabilities. The first block of the polymer was designed to con-jugate CD22-targeting monoclonal antibodies-linked to streptavi-din (αCD22) and the …
http://www.nature.com/articles/nnano.2009.341
Nov 22, 2009 · We report a novel intracellular delivery platform based on nanocapsules that consist of a single-protein core and thin polymer shell anchored covalently to the protein core.
https://www.thno.org/v09p3280.htm
2. Strategies for protein delivery. The cell membrane separates the interior of the cells from the extracellular environment and thus creates a discrete partition between internal and external environments [] that limits direct intracellular delivery of most compounds to only small molecules and ions capable of membrane diffusion [].Large molecules such as proteins, polypeptides, and ...
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00493
ConspectusThe use of protein to precisely manipulate cell signaling is an effective approach for controlling cell fate and developing precision medicine. More recently, programmable nucleases, such as CRISPR/Cas9, have shown extremely high potency for editing genetic flow of mammalian cells, and for treating genetic disorders. The therapeutic potential of proteins with an intracellular target ...Author: Jin Chang, Xianghan Chen, Xianghan Chen, Zachary Glass, Feng Gao, Lanqun Mao, Ming Wang, Qiaobing Xu
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