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https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Modulation of protein function is used to intervene in cellular processes but is often done indirectly by means of introducing DNA or mRNA encoding the effector protein. Thus far, direct intracellular delivery of proteins has remained challenging.Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.sciencedirect.com/science/article/pii/S0958166917302185
Intracellular protein delivery and vaccine development. Vaccines are arguably the most effective class of therapeutics ever developed. However, despite their success, vaccines still need to be developed for many pathogens, ranging from HIV to Hepatitis C. CD8 + T cells play an essential role in combating infections generated from viruses and cancer and there is consequently great interest in ...Author: Yumiao Zhang, Joachim Justad Røise, Kunwoo Lee, Jie Li, Niren Murthy
http://www.nature.com/articles/nnano.2009.341
Nov 22, 2009 · The intracellular use of therapeutic proteins is of great importance in the treatment of cancers and protein deficiency diseases. However, clinical applications remain rare, …
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201906187?af=R
Protein therapy offers promising prospects for the treatment of various important diseases, thus it is highly desirable to develop a robust carrier that can deliver active proteins into cells. The development of a novel protein delivery platform based on the self‐assembly of multiarmed amphiphilic cyclodextrins (CDEH) is reported.Author: Xiao He, Qipeng Long, Zhiying Zeng, Lan Yang, Yaqin Tang, Xuli Feng
https://pubs.rsc.org/en/content/articlelanding/2011/cs/c0cs00227e
Intracellular protein delivery holds enormous promise for biological and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein delivery using variousAuthor: Zhen Gu, Anuradha Biswas, Muxun Zhao, Yi Tang
https://www.ncbi.nlm.nih.gov/pubmed/28338410
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a ...Author: Moumita Ray, Yi-Wei Lee, Federica Scaletti, Ruijin Yu, Ruijin Yu, Vincent M Rotello
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151968/
Oct 16, 2007 · Protein delivery represents a powerful tool for experiments in live cells including studies of protein-protein interactions, protein interference with blocking antibodies, intracellular trafficking and protein or peptide biological functions. Most available reagents dedicated to the protein delivery allow efficient crossing of the plasma membrane.Author: Claire O. Weill, Stéphanie Biri, Abdennaji Adib, Patrick Erbacher
https://www.onlinelibrary.wiley.com/doi/full/10.1002/adma.201701086
One‐Pot Synthesis of Multiple Protein‐Encapsulated DNA Flowers and Their Application in Intracellular Protein Delivery. Eunjung Kim. Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ UK.Author: Eunjung Kim, Limor Zwi-Dantsis, Natalie Reznikov, Catherine S. Hansel, Shweta Agarwal, Molly M. Stev...
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00493
ConspectusThe use of protein to precisely manipulate cell signaling is an effective approach for controlling cell fate and developing precision medicine. More recently, programmable nucleases, such as CRISPR/Cas9, have shown extremely high potency for editing genetic flow of mammalian cells, and for treating genetic disorders. The therapeutic potential of proteins with an intracellular target ...Author: Jin Chang, Xianghan Chen, Xianghan Chen, Zachary Glass, Feng Gao, Lanqun Mao, Ming Wang, Qiaobing Xu
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes current approaches to the intracellular delivery of protein and peptide drugs.Author: Vladimir Torchilin
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