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https://www.sciencedirect.com/science/article/pii/S0168365911000198
Among these carriers, cationic polymers and peptides have been further developed as intracellular organelle-targeted delivery systems. The cytoplasm, nucleus and mitochondria have been considered primary targets for gene delivery using targeting moieties or environment-responsive materials.Author: Young-Wook Won, Kwang Suk Lim, Yong-Hee Kim
https://www.researchgate.net/publication/49774966_Intracellular_organelle-targeted_non-viral_gene_delivery_systems
Intracellular organelle-targeted non-viral gene delivery systems ... been further developed as intracellular organelle-targeted delivery systems. ... efficiency of nonviral gene delivery systems ...
https://www.researchgate.net/publication/51815471_Nanoparticles_for_intracellular-targeted_drug_delivery
Nanoparticles for intracellular-targeted drug delivery. ... systems as retinol, which is removed from the blood and bound ... nuclear access of nonviral gene delivery vectors J. Biol. Chem. 276 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://link.springer.com/chapter/10.1007/978-981-13-3642-3_12
The significant opportunities and challenges in further progress toward bench-to-bedside translation of organelle-targeted nanomedicines are discussed in this chapter. ... Novel drug delivery systems and regulatory affairs. ... Nonviral gene therapy: promises and challenges.Author: Sagar Dhoble, Shrikant Dhage, Sreeranjini Pulakkat, Vandana B. Patravale
https://pubs.acs.org/doi/abs/10.1021/bc9003525
In a nonviral gene delivery system, localization of a plasmid DNA in the nucleus is a prerequisite for expression of a desired therapeutic protein encoded in the plasmid DNA. In this study, a reducible polymer-based gene delivery system for improved intracellular trafficking and nuclear translocation of plasmid DNA is introduced. The system is consisted of two components, a plasmid DNA having ...Author: Ji Hoon Jeong, Ji Hoon Jeong, Sun Hwa Kim, Lane V. Christensen, Jan Feijen, Sung Wan Kim
https://pubs.acs.org/doi/10.1021/bc9003525
In a nonviral gene delivery system, localization of a plasmid DNA in the nucleus is a prerequisite for expression of a desired therapeutic protein encoded in the plasmid DNA. In this study, a reducible polymer-based gene delivery system for improved intracellular trafficking and nuclear translocation of plasmid DNA is introduced.Author: Ji Hoon Jeong, Ji Hoon Jeong, Sun Hwa Kim, Lane V. Christensen, Jan Feijen, Sung Wan Kim
https://www.sciencedirect.com/science/article/pii/S0006291X11000258
Research highlights Intracellular targeting of drugs can improve their therapeutic efficiency. We developed ‘IntraCell’ plugin for quantitative assessment of intracellular drug targeting. ‘IntraCell’ plugin revealed ER-targeting of novel nanoparticle-based delivery system. This plugin will be useful for development of novel formulations for biopharmaceuticals.Author: Hadas Sneh-Edri, David Stepensky
https://journals.sagepub.com/doi/10.1177/0883911513483507
May 23, 2013 · Nuclear location signal peptide–modified poly (ethyleneimine)/DNA complexes: An efficient gene delivery vector in vitro and in vivo Show all authors Hua Zhang 1Author: Hua Zhang, Zhongyan Liang, Wanli Li, Fangcai Li, Qixin Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718765/
Jul 17, 2013 · As of yet, most of the current nanoparticle formulations are not designed to deliver drugs/DNA to specific organelles inside the cell; pharmaceutical nanotechnology as applied to the level of cell organelles – the subcellular level – is an emerging field in drug delivery systems.11 However, several nanoparticles can be coated with organelle ...Author: Niraj M Sakhrani, Harish Padh
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