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https://www.sciencedirect.com/science/article/pii/S0168365911000198
Despite considerable research and achievement, only a few carriers have been identified that are able to selectively deliver genes to a target location. In this review, we explore the intracellular organelle-targeted non-viral gene delivery systems developed in the last decade . Download : …Author: Young-Wook Won, Kwang Suk Lim, Yong-Hee Kim
https://www.researchgate.net/publication/49774966_Intracellular_organelle-targeted_non-viral_gene_delivery_systems
Request PDF Intracellular organelle-targeted non-viral gene delivery systems Gene therapy is a rapidly growing approach for the treatment of various diseases. To achieve successful gene ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Current gene delivery systems are divided into three categories: viral-based, non-viral based, and combined hybrid systems. Viral gene delivery systems consist of viruses that are modified to be replication-deficient which can deliver genes to the target cells to provide expression.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747665/
The development of nanovehicular delivery systems for targeted delivery has been reviewed recently by Moghimi et al. 80 Active targeting of a therapeutic agent or a carrier is achieved by conjugating the therapeutic agent or the carrier to a tissue- or cell-specific ligand. 219,220 Passive targeting is achieved by coupling the therapeutic agent ...Author: Ales Prokop, Jeffrey M. Davidson
https://www.researchgate.net/publication/51815471_Nanoparticles_for_intracellular-targeted_drug_delivery
Nanoparticles for intracellular-targeted drug delivery. ... Several non-viral systems hav e been developed in recent years. ... nuclear access of nonviral gene delivery vectors J. Biol. Chem. 276 ...
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