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https://www.sciencedirect.com/science/article/pii/S0887899416302806
Intrathecal delivery methods enable the administration of soluble therapeutics directly into the central nervous system (CNS). As an intrathecal delivery method, the intracerebroventricular (ICV) route of administration instills therapy into the cerebral ventricles via an ICV port implanted under the scalp.Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.pedneur.com/article/S0887-8994(16)30280-6/fulltext
A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280.Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.sbir.gov/sbirsearch/detail/1570027
Intracerebroventricular Iduronidase Delivery to the Brain. Printer-friendly version. Award Information ... treatment of the disease in humans PROJECT NARRATIVE The goal of this proposal is to test a novel method of enzyme delivery to the brainIntravenous enzyme replacement therapy has proven successful for treating the somatic symptoms of ...
https://advances.sciencemag.org/content/3/12/e1701211.full
Dec 01, 2017 · Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells. 1San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cell and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy.Author: Alessia Capotondo, Rita Milazzo, Jose M. Garcia-Manteiga, Eleonora Cavalca, Annita Montepeloso, Bria...
https://link.springer.com/article/10.1007%2Fs12975-019-00692-0
Feb 28, 2019 · Our previous study indicated that nicotinamide phosphoribosyltransferase (NAMPT) is released from cells and might be an important extracellular neuroprotective factor in brain ischemia. Here, we tested whether NAMPT protects against ischemic brain injury when administered directly into the intracerebroventricular (ICV) compartment of the cranium.Author: Fenghua Chen, Zhongfang Weng, Qinghai Xia, Catherine Cao, Rehana K. Leak, Lihong Han, Jian Xiao, Ste...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679837/
May 12, 2013 · Both osmotic pumps and a single bolus injection can be used to deliver ASOs to the CSF. Pumps allow for a slow, continuous delivery, whereas the intracerebroventricular (ICV) bolus is a fast, one-time injection.Author: Sarah L. DeVos, Timothy M. Miller
https://www.sciencedirect.com/science/article/pii/S001448861000261X
Additionally, we evaluated whether continuous delivery of rhGC mediated by an AAV vector would have therapeutic impact. The significant efficacy of the gene therapy and intracerebroventricular approaches in this mouse model suggests a potential approach for treating patients affected by NGD. Materials and methods AnimalsAuthor: M.A. Cabrera-Salazar, S.D. Bercury, R.J. Ziegler, J. Marshall, B.L. Hodges, W.-L. Chuang, J. Pacheco...
https://www.neuromodulation.com/drug-delivery
Intraventricular drug delivery is the delivery of pain medication within the cerebrospinal fluid of the cistern (C1-2 vertebra) and intracranial ventricles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227174/
Oct 03, 2011 · One of these methods is injecting directly into cerebral lateral ventricles (Intracerebroventricular) which results in delivery of materials into the CNS through the cerebrospinal fluid 3,4. The second method is a temporal vein injection (intravenous) that can introduce different therapeutics into the circulatory system, leading to systemic delivery including the CNS 5 .Author: Jacqueline J. Glascock, Erkan Y. Osman, Tristan H. Coady, Ferrill F. Rose, Monir Shababi, Christian ...
https://en.wikipedia.org/wiki/Intracerebroventricular_injection
Intracerebroventricular injection (also called ICV injection, i.c.v. injection, or sometimes ICVI) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier.
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