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https://www.sciencedirect.com/science/article/pii/S0887899416302806
A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280.Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.sciencedirect.com/science/article/pii/S1096719218300192
Intrathecal delivery methods administer soluble therapeutics directly into the CSF. Intrathecal delivery methods include intracerebroventricular (ICV), intrathecal-lumbar and intracisternal routes. The ICV route enables the administration of drugs into a lateral cerebral ventricle via an implanted device (reservoir and catheter).Author: Irene Slavc, Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Jeanne Krauser, Daniel A. Lim, Marcos M...
https://www.pedneur.com/article/S0887-8994(16)30280-6/pdf
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations.
https://www.neuromodulation.com/drug-delivery
Intraventricular drug delivery is the delivery of pain medication within the cerebrospinal fluid of the cistern (C1-2 vertebra) and intracranial ventricles.
https://www.future-science.com/doi/full/10.4155/tde-2018-0002
There is a large body of animal research reporting that intracerebroventricular (ICV) oxytocin delivery, which is thought to diffuse oxytocin throughout the brain , modulates social behavior, although ICV delivered oxytocin may not necessarily reach all regions equivalently.Author: Daniel S Quintana, Knut T Smerud, Ole A Andreassen, Per G Djupesland
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679837/
May 12, 2013 · Both osmotic pumps and a single bolus injection can be used to deliver ASOs to the CSF. Pumps allow for a slow, continuous delivery, whereas the intracerebroventricular (ICV) bolus is a fast, one-time injection.Author: Sarah L. DeVos, Timothy M. Miller
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227174/
Oct 03, 2011 · One of these methods is injecting directly into cerebral lateral ventricles (Intracerebroventricular) which results in delivery of materials into the CNS through the cerebrospinal fluid 3,4. The second method is a temporal vein injection (intravenous) that can introduce different therapeutics into the circulatory system, leading to systemic delivery including the CNS 5 .Author: Jacqueline J. Glascock, Erkan Y. Osman, Tristan H. Coady, Ferrill F. Rose, Monir Shababi, Christian ...
https://en.wikipedia.org/wiki/Intracerebroventricular_injection
Intracerebroventricular injection (also called ICV injection, i.c.v. injection, or sometimes ICVI) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier.
https://www.researchgate.net/publication/26322515_Intracerebroventricular_Administration_of_Drugs
Intracerebroventricular drug administration is a method that bypasses the blood-brain barrier and other mechanisms that limit drug distribution into the brain, allowing high drug concentrations to enter the central compartment.
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