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https://link.springer.com/protocol/10.1007%2F978-1-61779-037-9_20
Feb 15, 2011 · Intranasal administration of synthetic siRNA is an effective modality of RNAi delivery for the prevention and therapy of respiratory diseases, including pulmonary infections. Vehicles used for nasal siRNA delivery include established as well as novel …Author: Sailen Barik
https://www.researchgate.net/publication/50833018_Intranasal_Delivery_of_Antiviral_siRNA
Intranasal administration of synthetic siRNA is an effective modality of RNAi delivery for the prevention and therapy of respiratory diseases, including pulmonary infections.Author: Sailen Barik
https://link.springer.com/protocol/10.1007%2F978-1-59745-191-8_6
The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.Author: Vira Bitko, Sailen Barik
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30098-2
Apr 11, 2018 · Intranasal siRNA Delivery RVG9R-siRNA complexes (formulated at a 25:1 peptide:siRNA molar ratio in 25 μl of PBS containing 5% glucose) were administered i.n. to mice (anesthetized i.p. with ketamine/xylazine hydrochloride) placed in a head down-and-forward position using a mouse positioning device (Signet Biotech).Author: Jagadish Beloor, Nyree Maes, Irfan Ullah, Pradeep Uchil, Andrew Jackson, Erol Fikrig, Sang Kyung Lee...
https://pubs.acs.org/doi/10.1021/acsnano.9b01892
Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury Shaowei Guo Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, IsraelAuthor: Shaowei Guo, Shaowei Guo, Nisim Perets, Oshra Betzer, Shahar Ben-Shaul, Anton Sheinin, Izhak Michael...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590831/
The siRNA delivery was found to be significant in cerebral cortex and cerebellum after 4 hrs of intranasal postdelivery. Furthermore, the biodistribution and toxicity characterization demonstrated maximum siRNA delivery in the brain with no visible, local toxic effects linked to delivery of the nanoparticle formulation at cellular levels.Author: Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Shyamali Saha, Satya Prakash
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185718/
Jul 09, 2010 · Although specificity and tissue delivery remain major bottlenecks in the clinical applications of RNAi in general, intranasal application of siRNA against respiratory viruses including, but not limited to influenza virus, has experienced significant success and optimism, which is reviewed here.Author: Sailen Barik
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