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https://www.researchgate.net/publication/264613524_A_Lysosome_-_Targeted_Drug_Delivery_System_Based_on_Sorbitol_Backbone_towards_Efficient_Cancer_Therapy
A Lysosome - Targeted Drug Delivery System Based on Sorbitol Backbone towards Efficient Cancer Therapy Article (PDF Available) in Organic & Biomolecular Chemistry 12(34) · July 2014 with 717 Reads
https://www.omicsonline.org/open-access/liposomes-for-drug-delivery-2155-952X276-97370.html
Drug encapsulation in a liposomal or lipid drug delivery system improves the pharmacokinetic and pharmacodynamic properties to such an extent that the drugs can be brought into regular use . Advantages of liposomes as a drug delivery system for antimicrobials are: • Improvement and control over pharmacokinetics and pharmacodynamics
https://pubs.rsc.org/en/content/articlelanding/2018/ra/c8ra00232k
Spider silks are attractive biopolymers due to their excellent mechanical properties and biomimetic potential. To optimize the electrostatic interaction for lysosomal drug delivery, a spider-eggcase-silk protein was genetically engineered using 5× His Tag with a tailor-made isoelectric point of 4.8. By a …
https://www.nature.com/articles/s41573-019-0036-1
Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal ...
http://www.thno.org/v08p3474.htm
Drug-delivering-drug platform-mediated potent protein therapeutics via a non-endo-lysosomal route . Xiaofei Xin 1, Chao Teng 1, Xiaoqing Du 1, Yaiqi Lv 1, Qingqing Xiao 1, Yubing Wu 1, Wei He 1, , Lifang Yin 1,2, 1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. 2.
https://experts.umn.edu/en/publications/rapid-endo-lysosomal-escape-of-polydl-lactide-co-glycolide-nanopa
Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: Implications for drug and gene delivery Jayanth Panyam, Wen Zhong Zhou, Swayam Prabha, Sanjeeb K. Sahoo, Vinod Labhasetwar Pharmaceutics
https://mct.aacrjournals.org/content/15/11/2688
In the present study, we tested the possibility of enhancing lysosomal delivery of ADCs by targeting a tumor-specific antigen in combination with an antigen that facilitates trafficking to the lysosomes. To this end, a bsADC was generated that combines tumor-specific targeting through HER2, with enhanced lysosomal delivery through CD63.
https://worldsymposia.org/worldsymposium-program-events-lysosomal-disease/program-lysosomal-research-care/
WORLDSymposium™ is an annual research conference dedicated to lysosomal diseases. WORLD is an acronym that stands for We’re Organizing Research on Lysosomal Diseases. Each year, WORLDSymposium presents the latest information from basic science, translational research, and clinical trials for lysosomal diseases.
https://link.springer.com/article/10.1007/s12274-019-2606-2
Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery. Herein, a novel photo-controllable metal-organic frameworks (MOFs) nanoswitch is rationally designed for enhancing small interfering RNA (siRNA) delivery. One single laser triggers the “off-to-on” switching of MOFs nanocomplexes, inducing significant siRNA release accompanied by rapid MOFs dissociation ...
https://www.researchgate.net/publication/5866301_Liposomal_Drug_Delivery_Systems_An_Update_Review
Liposomal Drug Delivery Systems: An Update Review ... This mode of drug delivery lends more safety and efficacy to administration of several classes of drugs like antiviral, antifungal ...
https://pubs.acs.org/doi/10.1021/acsnano.8b08246
Lysosomal acidification is indispensable to protein catabolism, which makes it an exploitable metabolic target for KRAS mutant pancreatic cancer. Herein we investigated ultra-pH-sensitive micelles (UPSM) with pH-specific buffering of organelle pH and rapid drug release as a promising therapy against pancreatic cancer.
https://onlinelibrary.wiley.com/doi/full/10.1002/asia.201500913
HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery. Hoyeon Lee. The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701 Korea. These authors contributed equally to this work. Search for more papers by this author. Soojin Uhm.
https://www.youtube.com/watch?v=vUqwIL5lgS8
Aug 18, 2016 · Liposomal technology is a method used by Cipla to improve the delivery of drugs. Liposomes offer excellent opportunity to selectively target drugs; which is expected to optimize the ...
https://en.wikipedia.org/wiki/Lysosomal
A lysosome (/ ˈ l aɪ s ə ˌ s oʊ m /) is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules.A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to ...
https://www.researchgate.net/publication/325802974_Drug-delivering-drug_platform-mediated_potent_protein_therapeutics_via_a_non-endo-lysosomal_route
Drug-delivering-drug platform-mediated potent protein therapeutics via a non-endo-lysosomal route ... microenvironments or inside cancer cells for on-demanded drug delivery and accumulation ...
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