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https://www.ncbi.nlm.nih.gov/pubmed/19324456
Intranasal delivery of cells to the brain. Danielyan L(1), Schäfer R, von Ameln-Mayerhofer A, Buadze M, Geisler J, Klopfer T, Burkhardt U, Proksch B, Verleysdonk S, Ayturan M, …Author: Lusine Danielyan, Richard Schäfer, Andreas von Ameln-Mayerhofer, Marine Buadze, Julia Geisler, Tim K...
https://www.sciencedirect.com/science/article/pii/S0171933509000211
Intranasal application of cells provides an alternative method of delivery to the brain that may reduce systemic exposure. However, further investigation is needed to elucidate the possible distribution of IN-applied cells outside of the brain and their fate within the brain after extended periods of time.Author: Lusine Danielyan, Richard Schäfer, Andreas von Ameln-Mayerhofer, Marine Buadze, Julia Geisler, Tim K...
https://www.ncbi.nlm.nih.gov/pubmed/21417782/
EXPERT OPINION: Intranasal delivery of stem cells is a new method with great potential for the transplantation of stem cells into the brain, and it may provide an extraordinary approach to overcoming the existing barriers of stem cell delivery for the treatment of many neurological disorders.Author: Yongjun Jiang, Juehua Zhu, Gelin Xu, Xinfeng Liu
https://www.researchgate.net/publication/24237215_Intranasal_delivery_of_cells_to_the_brain
The intranasal delivery of stem cells into the brain depends on the ability of cells to bypass the cribriform plate and enter the olfactory bulb partially via a parenchymal route 3. The ...
https://journals.lww.com/neurotodayonline/pages/articleviewer.aspx?year=2009&issue=08030&article=00002&type=Fulltext
They thought this might help the stem cells migrate better into the brain. In both cases, the stem cells reached the brain within one hour. When hyaluronidase was used, twice the number of stem cells made it into the brain. “We see these stem cells in the olfactory bulb, thalamus, hippocampus, and in the cortex,” Dr. Frey explained.
https://www.sciencedirect.com/science/article/pii/S0361923018303678
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://tbitherapy.com/wp-content/uploads/2014/06/IN-Stem-Cells-delivered-to-the-Brain-2009-EJCB-88-page-315.pdf
Here we demonstrate transnasal delivery of cells to the brain following intranasal application of fluorescently labeled rat mesenchymal stem cells (MSC) or human glioma cells to naive mice and rats. After cells crossed the cribriform plate, two migration routes were identified: (1) migration into the
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