We have collected information about Intranasal Delivery Of Cns Therapeutics for you. Follow the links to find out details on Intranasal Delivery Of Cns Therapeutics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Intranasal delivery to the CNS is an especially useful technique because not only is it rapid, but it targets the CNS reducing systemic exposure. For example, intranasal administration of deferoxamine to rats resulted in 3-19 times higher concentrations in brain regions with 28 times lower concentrations in the blood 11 .Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.ncbi.nlm.nih.gov/pubmed/19877171
Intranasal delivery is a noninvasive and convenient method that rapidly targets therapeutics to the CNS, bypassing the BBB and minimizing systemic exposure.Author: Shyeilla V. Dhuria, Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey, William H. Frey
https://www.sciencedirect.com/science/article/pii/S0022354916304841
INTRODUCTION. Despite the immense network of the cerebral vasculature, systemic delivery of therapeutics to the central nervous system (CNS) is not effective for greater than 98% of small molecules and for nearly 100% of large molecules. 1 The lack of effectiveness is due to the presence of the blood–brain barrier (BBB), which prevents most foreign substances, even many beneficial ...Author: Shyeilla V. Dhuria, Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey, William H. Frey
https://www.jove.com/video/4440/intranasal-administration-of-cns-therapeutics-to-awake-mice
Intranasal delivery to the CNS is an especially useful technique because not only is it rapid, but it targets the CNS reducing systemic exposure. For example, intranasal administration of deferoxamine to rats resulted in 3-19 times higher concentrations in brain regions with …Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-18-007.html
Nasal delivery of therapeutics may offer several advantages. It is thought that therapeutics, large or small, can directly enter the central nervous system (CNS) and/or CSF through the olfactory nerve via extracellular diffusion, axonal transport and/or other unknown mechanism(s).
https://www.sbir.gov/node/1249539
Nasal delivery of therapeutics may offer several advantages. It is thought that therapeutics, large or small, can directly enter the central nervous system (CNS) and/or cerebrospinal fluid (CSF) through the olfactory nerve via extracellular diffusion, axonal transport and/or other unknown mechanism (s).
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery does not necessarily require any modification to therapeutic agents. A wide variety of therapeutics, including both small molecules and macromolecules, can be targeted to the olfactory system and connected memory areas affected by Alzheimer's disease. Using the intranasal delivery system,...Author: Leah R Hanson, William H Frey, William H Frey
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · The key factors that determine the efficacy of delivery via this route include the following: delivery to the olfactory area of the nares as opposed to the respiratory region, a longer retention time at the nasal mucosal surface, penetration enhancement of the active through the nasal epithelia, and a reduction in drug metabolism in the nasal cavity.Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
Impel NeuroPharma is developing transformative therapies for people suffering from central nervous system disorders with high unmet medical needs. We are developing therapies that have the potential to deliver injection-like clinical outcomes via our proprietary formulations and upper nasal delivery technology – Precision Olfactory Delivery ...
https://www.mdedge.com/neurology/article/106892/alzheimers-cognition/intranasal-drug-delivery-bypasses-blood-brain-barrier
Intranasal delivery of therapeutics involves spraying therapeutics into the upper part of the nasal cavity to enable them to follow these olfactory axon bundles directly into the brain through foramena in the cribriform plate. Once across the cribriform plate,...
Searching for Intranasal Delivery Of Cns Therapeutics?
You can just click the links above. The data is collected for you.
