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https://www.sciencedirect.com/science/article/pii/B9780128018880000229
Intracoronary infusion has been the most popular mode of stem cell delivery in the clinical setting, especially after AMI. The intracoronary delivery of stem cells has been shown to be safe at 4–9 days after an AMI in the clinical setting , , , , , , .The stop-flow technique used for intracoronary delivery is similar to that used for coronary angioplasty, which involves over-the-wire ...Author: Emerson C. Perin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976938/
By combining PET, μCT, and MRI with histological evaluation of engraftment as well as measurements of contractility and tissue viability, we have provided persuasive evidence that intracoronary delivery of respiration-competent mitochondria was a feasible and effective means to protect injured hearts from ischemia-reperfusion injury.Author: Douglas B. Cowan, Rouan Yao, Vamsidhar Akurathi, Erin R. Snay, Jerusha K. Thedsanamoorthy, David Zur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983442/
Intracoronary delivery. Selective intracoronary cell delivery involves cell infusion, generally through the central lumen of a balloon catheter positioned in the coronary artery. Cells can be injected while either maintaining coronary flow or following interruption of flow with …Author: Quang T Bui, Zachary M Gertz, Robert L Wilensky
https://www.sciencedirect.com/science/article/pii/S193687981000511X
Objectives. We investigated whether local abciximab delivery to the site of intracoronary thrombus is more effective than intracoronary bolus infusion in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention and downstream clopidogrel administration.Author: Francesco Prati, Davide Capodanno, Tomasz Pawlowski, Vito Ramazzotti, Mario Albertucci, Alessio La M...
https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.114.001478
The aim of the present study was to test the feasibility of intracoronary delivery of IK-5001 in patients recovering from a large MI. The present report describes the first human experience using IK-5001 in survivors of a moderate-to-large MI, and its findings could open up new options in the treatment of LV remodeling and heart failure after MI.Author: Norbert Frey, Axel Linke, Tim Süselbeck, Jochen Müller-Ehmsen, Paul Vermeersch, Danny Schoors, Mark ...
http://basictranslational.onlinejacc.org/content/5/2/208
Feb 01, 2020 · We have read with interest the paper by Shin et al. that demonstrates that intracoronary delivery of mitochondria affords protection against ischemia–reperfusion injury in pigs ([1][1]). This study is presented as a necessary step toward the assessment of a similar approach in human subjects whoAuthor: Alberto Aimo, Michele Emdin, Claudio Passino
https://www.nature.com/articles/s41569-020-0340-9
Jan 24, 2020 · “Intracoronary delivery of mitochondria to the myocardium provides a variety of possible applications for both percutaneous and surgical therapies by exploiting its multifactorial rescue of ...Author: Gregory B. Lim
https://clinicaltrials.gov/ct2/show/NCT02549625
The objective of this study is to determine the safety and feasibility of autologous mononuclear cells (MNC) collected from bone marrow (BM) and intracoronary delivery for individuals with declining performance of their single right ventricle systemic pumps.
http://basictranslational.onlinejacc.org/content/4/8/871
Dec 01, 2019 · Intracoronary mitochondrial delivery after temporary regional ischemia significantly improved myocardial function, perfusion, and infarct size. The authors concluded that intracoronary delivery of mitochondria is safe and efficacious therapy for myocardial ischemia-reperfusion injury.Author: Borami Shin, Borami Shin, Mossab Y. Saeed, Mossab Y. Saeed, Jesse J. Esch, Jesse J. Esch, Alvise Gua...
https://www.ahajournals.org/doi/full/10.1161/01.cir.96.1.154
Site-specific delivery has been proposed to result in higher concentrations of chemical compounds at the site of angioplasty. 12 13. Because previously used methods for quantification require tissue sampling, evaluation of the effectiveness of site-specific intracoronary delivery of drugs has been confined thus far to animal studies.Author: Edoardo Camenzind, Willem H. Bakker, Ambroos Reijs, Ingeborg M. van Geijlswijk, Eric Boersma, Michae...
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