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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084214/
Intranasal transmucosal delivery of benzodiazepines is useful in reducing time to drug administration and cessation of seizures in the pre-hospital setting, when actively seizing patients arrive in the emergency room, and at home where care-givers treat their dependents.Author: Daniel P. Wermeling
https://www.ncbi.nlm.nih.gov/pubmed/19332330
Intranasal transmucosal delivery of benzodiazepines is useful in reducing time to drug administration and cessation of seizures in the pre-hospital setting, when actively seizing patients arrive in the emergency room, and at home where caregivers treat their dependents.Author: Daniel P. Wermeling
https://www.sciencedirect.com/science/article/pii/S1933721309000038
Nasal drug delivery of midazolam for treatment of seizures in the home-bound setting has been successful in preliminary studies.41, 42, 43 Clearly, morbidity and mortality, the intensity of health-care resources and expenses associated with treatment of epileptic patients could be reduced if an effective and safe transmucosal treatment was available for use by caregivers.Author: Daniel P. Wermeling
https://link.springer.com/article/10.1016%2Fj.nurt.2009.01.002
Apr 01, 2009 · Intranasal transmucosal delivery of benzodiazepines is useful in reducing time to drug administration and cessation of seizures in the pre-hospital setting, when actively seizing patients arrive in the emergency room, and at home where care-givers treat their dependents.Author: Daniel P. Wermeling
https://www.researchgate.net/publication/24244665_Intranasal_Delivery_of_Antiepileptic_Medications_for_Treatment_of_Seizures
For example, intranasal administration is advantageous in the home treatment of prolonged seizures, in the treatment of pre-hospital seizures by emergency medical technicians (EMTs), and in the ...Author: Daniel Wermeling
https://www.semanticscholar.org/paper/Intranasal-delivery-of-antiepileptic-medications-of-Wermeling/98dc1ab0e3f4c71f6ac2dc1a865cf86b2e258b87
Neuropeptides delivered intranasally, crossing the blood-brain barrier via the olfactory system, may increase the availability of medications for treatment of epilepsy. Consequently, there remains a significant unmet medical need to serve the pharamcotherapeutic requirements of epilepsy patients through commercial development and marketing of intranasal antiepileptic products.
https://link.springer.com/content/pdf/10.1016%2Fj.nurt.2009.01.002.pdf
Intranasal Delivery of Antiepileptic Medications for Treatment of Seizures. Daniel P. Wermeling. Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky 40536-0082. Summary:Acuteisolatedseizure,repetitiveorrecurrentseizures, and status epilepticus are all deemed medical emergencies.Author: Daniel P. Wermeling
http://www.intranasal.net/SeizureRx/default.htm
As often stated in this web site, nasal drug delivery is simply another tool for delivering anti-seizure medications rapidly while IV therapy is a higher “gold standard” in many clinical settings and should be established based on patient severity of illness.
https://reference.medscape.com/drug/nayzilam-midazolam-intranasal-1000286
Indicated for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy aged ≥12 years. <12 years: Safety and efficacy not established.
https://www.epilepsy.com/article/2015/9/nasal-therapy-seizure-emergencies
Sep 23, 2015 · Nasal Therapy: A Potential Solution for Seizure Emergenices Spraying a benzodiazepine into someone's nose may potentially be one of the most sensible solutions for people with seizures. It has been established that medications can be easily absorbed in the lining of the nasal cavity (such as allergy medications and certain vaccinations).
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