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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104330/
The antidepressant-like effect of the interfering peptide can be detected for 2 h after intranasal administration. Furthermore, we show that the interfering peptide disrupts the D1–D2 interaction and it can be detected in the prefrontal cortex after intranasal administration.Author: Virginia Brown, Fang Liu, Fang Liu
https://www.nature.com/articles/npp201461
Mar 17, 2014 · The antidepressant-like effect of the interfering peptide can be detected for 2 h after intranasal administration. Furthermore, we show that the interfering peptide …Author: Virginia Brown, Fang Liu, Fang Liu
https://www.researchgate.net/publication/260841912_Intranasal_Delivery_of_a_Peptide_with_Antidepressant-Like_Effect
Intranasal Delivery of a Peptide with Antidepressant-Like Effect. A critical issue in drug development is developing effective, non-invasive delivery routes to the central nervous system (CNS). Major depressive disorder (MDD) is an illness associated with significant morbidity.
https://www.ncbi.nlm.nih.gov/pubmed/25222984
1. Ther Deliv. 2014 May;5(5):503. Intranasal peptide delivery demonstrates antidepressant-like effect. [No authors listed] PMID: 25222984 [Indexed for MEDLINE]
https://www.sciencedirect.com/science/article/pii/S0196978116302364
Intranasal (i.n.) delivery offers a non-invasive alternative for getting protein and peptide drugs into the brain by utilizing olfactory neuronal distribution pathway in the cribriform plate, which may lead to direct nose-to-brain drug distribution.Author: Sachie Sasaki-Hamada, Ryuji Nakamura, Yusuke Nakao, Toshiki Akimoto, Emi Sanai, Mio Nagai, Michiko H...
https://www.ncbi.nlm.nih.gov/pubmed/27894924
Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice. Sasaki-Hamada S(1), Nakamura R(2), Nakao Y(3), Akimoto T(2), Sanai E(2), Nagai M(3), Horiguchi M(4), Yamashita C…Author: Sachie Sasaki-Hamada, Ryuji Nakamura, Yusuke Nakao, Toshiki Akimoto, Emi Sanai, Mio Nagai, Michiko H...
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14774
the first successful approach for intranasal delivery of relaxin‐3 or the 14s21 (i,i+7) stapled peptide to achieve anxiolytic and antidepressant‐ like activity in animal models.Author: Subhi Marwari, Anders Poulsen, Norrapat Shih, Rajamani Lakshminarayanan, R. Manjunatha Kini, Charles...
https://www.ncbi.nlm.nih.gov/pubmed/31061348
This review focuses on the anti-dementia and antidepressant-like effects of peptides including glucagon-like peptide (GLP)-1, GLP-2, neuromedin U (NmU), and oxytocin, and the intranasal delivery of these peptides to the brain.Author: Jun-Ichiro Oka
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476983/
Mar 24, 2015 · Intranasal delivery of proteins and peptides to the CNS provides a means to bypass the BBB in the treatment of neurodegenerative diseases like Alzheimer’s disease (AD). However, simply enabling them to enter the brain is not enough to ensure that it will have a beneficial effect on CNS functions such as cognition.Author: M. Elizabeth Meredith, Therese S. Salameh, William A. Banks
https://www.researchgate.net/publication/6963259_Intravail_Highly_effective_intranasal_delivery_of_peptide_and_protein_drugs
For pharmaceutical companies, Intravail provides a means to capitalise on two important industry dynamics: rapidly growing industry interest in commercialising peptide and protein drugs, and increasing interest in, and use of, the intranasal route for systemic drug delivery.
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