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https://www.ncbi.nlm.nih.gov/pubmed/3722629
Intracellular cysteine and glutathione delivery systems. Meister A, Anderson ME, Hwang O. Glutathione functions in catalysis, metabolism, transport, and reductive processes and in protection of cells by destruction of free radicals, reactive oxygen intermediates, and other toxic compounds of endogenous and exogenous origin.Author: Meister A, Anderson Me, Hwang O
https://www.pnas.org/content/79/20/6246
Oct 01, 1982 · Depletion of glutathione by inhibition of its synthesis by buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, leads to increased sensitivity to (i) irradiation and (ii) oxidative stress. In the present work, an intracellular cysteine delivery system was used to promote glutathione synthesis, and this was found to protect against toxicity. Thus ...Author: J M Williamson, B Boettcher, A Meister
https://www.sciencedirect.com/science/article/pii/0076687987430590
INTRACELLULAR DELIVERY OF CYSTEINE 319 [ 5 7 ] Administration of L-2-Oxothiazolidine 4-Carboxylate as an Intracellular Cysteine Delivery System The studies that led to this procedure included the following find- ings16,33,34: (1) L-2-Oxothiazolidine 4-carboxylate is a good substrate of 5- …Author: Mary E. Anderson, Alton Meister
https://www.sciencedirect.com/science/article/pii/S0168365911000368
8. Glutathione-responsive gene delivery systems. In the past several years, significant effort has been directed to development of reduction-responsive gene delivery systems , . The dynamic chemical stability of disulfide bonds, i.e. superior stability under the extracellular environments and rapid degradation in the intracellular reducing ...Author: Ru Cheng, Fang Feng, Fenghua Meng, Chao Deng, Jan Feijen, Zhiyuan Zhong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566166/
May 11, 2019 · Glutathione (GSH) is a low molecular weight, water-soluble thiol that is present in all eukaryotic cells . It is synthesized from the amino acids glutamate, cysteine, and glycine, produced exclusively in the cytosol , and transported to other subcellular organelles, including mitochondria , endoplasmic reticulum , and the nucleus .Author: Rebecca L. Gould, Robert Pazdro
https://www.researchgate.net/publication/16240147_Intracellular_cysteine_delivery_system_that_protects_against_toxicity_by_promoting_GSH_synthesis
Intracellular cysteine delivery system that protects against toxicity by promoting GSH synthesis. ... Depletion of glutathione by inhibition of its synthesis by buthionine sulfoximine, an ...
https://patents.google.com/patent/US4784685A/en
US4784685A US07/068,306 US6830687A US4784685A US 4784685 A US4784685 A US 4784685A US 6830687 A US6830687 A US 6830687A US 4784685 A US4784685 A US 4784685A Authority US United States Prior art keywords glutathione ester method gsh plant Prior art date 1985-04-22 Legal status (The legal status is an assumption and is not a legal conclusion.Author: Alton Meister
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