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https://www.intechopen.com/books/novel-gene-therapy-approaches/extracellular-and-intracellular-barriers-to-non-viral-gene-transfer
To maximize non-viral gene delivery, levels of expression must be improved. Unfortunately, many extracellular and intracellular barriers (including the extracellular environment, immune scavengers, the cell membrane, endosomal escape, the cytoskeletal network and the nuclear membrane) preclude efficient gene transfer.Author: Lynn F. Gottfried, David A. Dean
https://www.researchgate.net/publication/11269723_Intracellular_Barriers_to_Non-Viral_Gene_Transfer
Intracellular Barriers to Non-Viral Gene Transfer Current Gene Therapy, 2002, Vol. 2, No. 2 7 Nuclear Delivery of Plasmid DNA The significant size of plasmid DNA (2-10 MDa) makes
https://www.ncbi.nlm.nih.gov/pubmed/12109215
Intracellular barriers to non-viral gene transfer. ... has been the subject of intensive investigations to improve our understanding of cellular and extracellular barriers impeding gene delivery. Here, we review those physical and metabolic impediments that account, at least in part, for the inefficient translocation of transgene into the ...Author: Delphine Lechardeur, Gergely L. Lukacs
https://www.slideshare.net/Aparajitha_Anne/gene-delivery-system
May 19, 2012 · GENE DELIVERY:• In most gene delivery studies a normal gene is inserted into the genome to replace an abnormal disease causing gene.• A carrier molecule called vector carries the therapeutic gene to patient’s target cells. Vectors generally used are viruses.•
https://www.researchgate.net/publication/8991580_Extracellular_and_intracellular_barriers_in_non-viral_gene_delivery_1
Low transfection efficiency of nonviral gene delivery vectors results mainly from multiple extracellular and intracellular barriers.1, 2 Among the intracellular barriers, endosomal escape has been ...
https://www.doctorabel.us/cell-therapy/iv-extracellular-barriers-for-gene-delivery.html
Sep 17, 2018 · In vitro gene delivery and ex vivo gene therapy approaches are predominantly concerned with gene delivery barriers presented by the cell itself. In vivo gene therapy must also be concerned with extracellular barriers, where the route of administration of the therapeutic gene also plays a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · EXTRA- AND INTRACELLULAR BARRIERS FOR GENE DELIVERY. Several anatomical and cellular barriers limit the overall efficiency of gene transfer by nonviral methods (Fig. 1).Anatomical barriers are epithelial, endothelial cell linings and the extracellular matrix surrounding the cells that prevent direct access of macromolecules to the target cells.Author: Mohammed S. Al-Dosari, Xiang Gao
http://www.eurekaselect.com/64632/article
Keywords:Intracellular Barriers, Gene Transfer, ENDO-LYSOSOMAL, Lipoplex, Endocytosis, Wheat germ agglutinin. Abstract: Non-viral vector mediated gene transfer, compared to viral vector mediated one, is a promising tool for the safe delivery of therapeutic DNA in genetic and acquired human diseases. Although the lack of specific immune response ...Author: Delphine Lechardeur, Gergely L. Lukacs
https://www.powershow.com/viewfl/1b3e4f-ZDc1Z/Gene_Delivery_powerpoint_ppt_presentation
Intracellular Pathway Three barriers of gene delivery Cell Membrane Endosomal membrane Nuclear membrane 12 In Vitro Vs In Vivo Delivery 13 Barriers Of Gene Delivery 14 Gene Carrier Systems. Viral Vectors Non-viral Vectors ; ... The PowerPoint PPT presentation: "Gene Delivery" is the property of …
https://www.sciencedirect.com/science/article/pii/S0168365903003973
Extracellular and intracellular barriers in non-viral gene delivery ... Non-viral gene delivery systems are, however, less efficient than the viral systems. Cationic liposomes (lipoplexes) and cationic polymers are the most frequently used non-viral gene transfer systems. Once in contact with negatively charged DNA, these lipids and polymers ...Author: Marika Ruponen, Paavo Honkakoski, Seppo Rönkkö, Jukka Pelkonen, Markku Tammi, Arto Urtti
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