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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763210/
Aug 22, 2018 · Intracellular delivery of genome editing molecules is another area where intracellular delivery of proteins may lead to advances from basic biology to cell-based therapies.Author: Martin P. Stewart, Martin P. Stewart, Robert Langer, Klavs F. Jensen
https://www.springer.com/gp/book/9789400712478
Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201711651
Intracellular delivery of therapeutic proteins is highly challenging and in most cases requires chemical or genetic modifications. Herein, two complementary approaches for endocytosis‐independent delivery of proteins to live mammalian cells are reported.Author: Linghui Qian, Jiaqi Fu, Peiyan Yuan, Shubo Du, Wei Huang, Lin Li, Shao Q. Yao
https://pubs.acs.org/doi/10.1021/acsnano.9b07930
Intracellular delivery of functional macromolecules, such as DNA and RNA, across the cell membrane and into the cytosol, is a critical process in both biology and medicine.Author: GeoumYoung Kang, Daniel W. Carlson, Tae Ho Kang, Seungki Lee, Simon J. Haward, Inhee Choi, Amy Q. Sh...
https://www.ncbi.nlm.nih.gov/pubmed/30469344
Nov 21, 2018 · Intracellular delivery is a critical step in biological discoveries and has been widely utilized in biomedical research. A variety of molecular tools have been developed for cell-based gene therapies, including FDA approved CAR-T immunotherapy, iPSC, cell reprogramming and gene editing.Author: Junfeng Shi, Yifan Ma, Jing Zhu, Yuanxin Chen, Yating Sun, Yicheng Yao, Zhaogang Yang, Jing Xie
https://www.ncbi.nlm.nih.gov/pubmed/28338410
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue.Author: Moumita Ray, Yi-Wei Lee, Federica Scaletti, Ruijin Yu, Ruijin Yu, Vincent M Rotello
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