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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065132/
Apr 14, 2014 · Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465146/
A pulsatile drug delivery system is characterized by a lag time that is an interval of no drug release followed by rapid drug release. The purpose of this work was to develop hollow calcium alginate beads for floating pulsatile release of valsartan intended for chronopharmacotherapy.
https://www.scholarsresearchlibrary.com/articles/formulation-and-evaluation-of-floating-pulsatile-drug-delivery-system-of-metoprolol-tartrate.pdf
The floating pulsatile drug delivery system was designed such that rapid release core tablet of MT was dry coated by the layer of HPMC to impart pulsatile release characteristics and the top cover buoyant layer ensured the floating of the system (figure 1). Developed formulations wereAuthor: Anuradha K. Salunkhe, Remeth J. Dias, Kailas K. Mali, Niranjan S. Mahajan, Vishwajeet S. Ghorpade
https://www.sciencedirect.com/science/article/pii/S0378517399001891
The objective of this study was to develop and evaluate floating and pulsatile drug delivery systems based on a reservoir system consisting of a drug-containing effervescent core and a polymeric coating. Preliminary studies identified important core and coating properties for the two systems.Author: Ina Krögel, Roland Bodmeier
https://www.researchgate.net/publication/281557318_Floating_pulsatile_drug_delivery_system_a_review
A blend of floating and pulsatile principles of drug delivery system seems to present the advantage that a drug can be released in the upper GI tract after a definite time period of no drug release.
https://www.mdpi.com/1999-4923/12/1/52
Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing . by Nagi Reddy Dumpa 1, Suresh Bandari 1 and Michael A. Repka 1,2,* 1. Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA ...Author: Nagi Reddy Dumpa, Suresh Bandari, Michael A. Repka
https://www.researchgate.net/publication/7416087_Floating_Drug_Delivery_Systems_A_Review
Floating Drug Delivery Systems: A Review ... utilized in the d evelopment of floating or pulsatile drug . delivery system based on the coated effervescent core.
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